store at low temperature
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
CHDI-390576 is a CNS penetrant class IIa HDAC inhibitor (IC50s: 54 nM, 60 nM, 31 nM, 50 nM for class IIa HDAC4, HDAC5, HDAC7, HDAC9). It shows >500-fold selectivity over class I HDACs (1, 2, 3) and ~150-fold selectivity over HDAC8 and the class IIb HDAC6 isoform.
説明 | CHDI-390576 is a CNS penetrant class IIa HDAC inhibitor (IC50s: 54 nM, 60 nM, 31 nM, 50 nM for class IIa HDAC4, HDAC5, HDAC7, HDAC9). It shows >500-fold selectivity over class I HDACs (1, 2, 3) and ~150-fold selectivity over HDAC8 and the class IIb HDAC6 isoform. |
ターゲット&IC50 | HDAC8:9.1 μM, HDAC6 (human):6.2 μM, HDAC1:39.7 μM, HDAC9 (human):50 nM, HDAC3:25.8 μM, HDAC5:60 nM, HDAC7:31 nM, HDAC4:54 nM |
分子量 | 391.32 |
分子式 | C19H13F4N3O2 |
CAS No. | 1629729-98-1 |
store at low temperature
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
You can also refer to dose conversion for different animals. 詳細
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CHDI-390576 1629729-98-1 Chromatin/Epigenetic DNA Damage/DNA Repair HDAC CHDI390576 CHDI 390576 Inhibitor inhibitor inhibit