Powder: -20°C for 3 years | In solvent: -80°C for 1 year
CM-675 is a dual inhibitor of phosphodiesterase 5 (PDE5) and class I histone deacetylases (IC50s: 114 nM and 673 nM for PDE5 and HDAC1) with the potential to treat Alzheimer’s disease.
説明 | CM-675 is a dual inhibitor of phosphodiesterase 5 (PDE5) and class I histone deacetylases (IC50s: 114 nM and 673 nM for PDE5 and HDAC1) with the potential to treat Alzheimer’s disease. |
ターゲット&IC50 | PDE5:114 nM nM |
In vitro | CM-675 (29a) demonstrates a pronounced time-dependent inhibitory effect on class I HDACs, particularly HDAC2. Its potency against HDAC1 also significantly enhances over time, showing increased inhibition (~1 log unit) at varying pre-incubation intervals: 673 nM at 30 minutes, 180 nM at 4 hours, and 69 nM at 6 hours[1]. |
分子量 | 536.62 |
分子式 | C31H32N6O3 |
CAS No. | 1872466-47-1 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 22.5 mg/mL (41.9 mM), Sonication and heating to 60℃ are recommended.
You can also refer to dose conversion for different animals. 詳細
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.
CM-675 1872466-47-1 Chromatin/Epigenetic DNA Damage/DNA Repair Metabolism HDAC PDE CM675 CM 675 Inhibitor inhibitor inhibit