store at low temperature
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
CP-66948 is a potent histamine H2 receptor antagonist with inhibitory effect on gastric acid secretion and can be used to protect gastric and intestinal mucosa.
説明 | CP-66948 is a potent histamine H2 receptor antagonist with inhibitory effect on gastric acid secretion and can be used to protect gastric and intestinal mucosa. |
In vivo | CP-66,948 exhibits an affinity for the guinea pig atria histamine H2-receptor that is 15 times greater than that of cimetidine and seven times greater than that of ranitidine. In vivo, the ED50 value for the inhibition of gastric acid secretion in pylorus-ligated rats is 2 mg/kg intraduodenally. In histamine or pentagastrin-stimulated Heidenhain pouch dogs, the antisecretory ED50 values are 0.3 mg/kg per os and 1.0 mg/kg per os, respectively. CP-66,948 also demonstrates inhibition of ethanol-induced gastric hemorrhagic lesions in rats following either oral or systemic administration, with ED50 values of 12 mg/kg per os and 6 mg/kg subcutaneously[1]. |
分子量 | 292.4 |
分子式 | C13H20N6S |
CAS No. | 101189-47-3 |
store at low temperature
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
You can also refer to dose conversion for different animals. 詳細
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CP-66948 101189-47-3 GPCR/G Protein Immunology/Inflammation Neuroscience Histamine Receptor CP 66948 CP66948 Inhibitor inhibitor inhibit