Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Amitriptyline (MK-230, N-750, Ro41575) is a tricyclic antidepressant (TCA) with analgesic properties. Amitriptyline is widely used to treat depression and neuropathic pain.
パッケージサイズ | 在庫状況 | 単価(税別) |
---|---|---|
10 mg | お問い合わせ | ¥ 9,000 |
25 mg | お問い合わせ | ¥ 14,500 |
50 mg | お問い合わせ | ¥ 21,000 |
100 mg | お問い合わせ | ¥ 30,500 |
200 mg | お問い合わせ | ¥ 45,500 |
説明 | Amitriptyline (MK-230, N-750, Ro41575) is a tricyclic antidepressant (TCA) with analgesic properties. Amitriptyline is widely used to treat depression and neuropathic pain. |
ターゲット&IC50 | SERT:3.45 nM (ki), 5-HT2:235 nM (ki), σ1 receptor:287 nM (ki), H1 receptor:0.5 nM (ki), NET:13.3 nM (ki), H4 receptor:7.31 nM (ki) |
In vitro | Amitriptyline inhibits both serotonin transporter (SERT) and norepinephrine transporter (NET) with Ki of 3.45 nM and 13.3 nM, respectively. Amitriptyline is also an inhibitor of histamine receptor H1, histamine receptor H4, 5-HT2 and sigma 1 receptor with Ki of 0.5 nM, 7.31 nM, 235 nM and 287 nM, respectively. |
分子量 | 277.4 |
分子式 | C20H23N |
CAS No. | 50-48-6 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
H2O: 9.7 mg/mL (34.96 mM)
You can also refer to dose conversion for different animals. 詳細
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Amitriptyline 50-48-6 GPCR/G Protein Immunology/Inflammation Neuroscience Sigma receptor 5-HT Receptor Histamine Receptor Norepinephrine Inhibitor inhibitor inhibit