store at low temperature
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Capsiate is an orally active TRPV1 agonist, a non-irritating capsaicin analog that acts as an antiallergic agent with anti-inflammatory, antioxidant, hypoglycemic, and inhibitory angiogenic activity.
説明 | Capsiate is an orally active TRPV1 agonist, a non-irritating capsaicin analog that acts as an antiallergic agent with anti-inflammatory, antioxidant, hypoglycemic, and inhibitory angiogenic activity. |
ターゲット&IC50 | TRPV1:290 nM(EC50) |
In vitro |
Capsiate evokes current responses in HEK293 cells expressing TRPV1[3]. Capsiate (5 to 25 µM) inhibits Src in, as well as VEGF-induced proliferation of and tube formation by, human umbilical vein endothelial cells (HUVECs).[1] |
In vivo |
Capsiate (0.03~0.54 mM; s.c.) induces nociceptive responses in mice.[3] Topical application of Capsiate reduces antigen-induced increases in ear thickness in a mouse model of passive cutaneous anaphylaxis and decreases epidermal thickness and eosinophil and mast cell infiltration in a mouse model of atopic dermatitis.[3] Capsiate (10 mg/kg) decreases body weight gain and perirenal fat weight, as well as increases oxygen consumption, fat oxidation, and carbohydrate oxidation, in a mouse model of ad libitum feeding-induced weight gain.[4] |
分子量 | 306.4 |
分子式 | C18H26O4 |
CAS No. | 205687-01-0 |
store at low temperature
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 90.0 mg/mL (293.7 mM), Sonication is recommended.
You can also refer to dose conversion for different animals. 詳細
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.
Capsiate 205687-01-0 Membrane transporter/Ion channel oxidation-reduction TRP/TRPV Channel Antioxidant Inhibitor inhibitor inhibit