Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Casopitant mesylate (GW679769B) is a selective, brain permeable, and orally active antagonist of neurokinin 1 (NK1) receptor. It is a second in the class of antiemetics.
パッケージサイズ | 在庫状況 | 単価(税別) |
---|---|---|
25 mg | 約8-10 週間 | ¥ 305,500 |
50 mg | 約8-10 週間 | ¥ 399,500 |
100 mg | 約8-10 週間 | ¥ 638,000 |
説明 | Casopitant mesylate (GW679769B) is a selective, brain permeable, and orally active antagonist of neurokinin 1 (NK1) receptor. It is a second in the class of antiemetics. |
In vivo | In a ferret-model of Cisplatin-induced emesis, Casopitant inhibits retching and vomiting and reduced nausea-like behaviours in a dose-dependent manner. Following a single intraperitoneal dose, radioactive labeled Casopitant ([14C]Casopitant) is rapidly absorbed, with plasma and brain concentrations being approximately equal at two hours post-dosing. [14C]Casopitant is found in the brain as the parent compound and two major oxidative metabolites (M1 and M2), accounting for approximately 76%, 19%, and 3% of the radioactivity, respectively. Casopitant possesses a high affinity for brain NK1 receptors in the ferret [2]. |
別名 | GW679769B |
分子量 | 712.72 |
分子式 | C31H39F7N4O5S |
CAS No. | 414910-30-8 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
You can also refer to dose conversion for different animals. 詳細
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Casopitant mesylate 414910-30-8 GPCR/G Protein Metabolism Neuroscience P450 Neurokinin receptor Casopitant Mesylate GW679769B Inhibitor inhibitor inhibit