Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Coralyne chloride is a protoberberine with strong anticancer activity. It can be used to prepare Coralyne derivatives, a fluorescent DNA-based molecular rectifier built into DNA duplexes through site-specific insertion. It acts as a topoisomerase I toxic molecule, inducing topoisomerase I-mediated DNA cleavage.
パッケージサイズ | 在庫状況 | 単価(税別) | |||
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サンプルについてお問い合わせ | |||||
1 mg | 在庫あり | ¥ 7,500 | |||
2 mg | 在庫あり | ¥ 10,500 | |||
5 mg | 在庫あり | ¥ 16,500 | |||
10 mg | 在庫あり | ¥ 29,500 | |||
25 mg | 在庫あり | ¥ 66,500 | |||
50 mg | 在庫あり | ¥ 104,500 | |||
100 mg | 在庫あり | ¥ 154,500 |
説明 | Coralyne chloride is a protoberberine with strong anticancer activity. It can be used to prepare Coralyne derivatives, a fluorescent DNA-based molecular rectifier built into DNA duplexes through site-specific insertion. It acts as a topoisomerase I toxic molecule, inducing topoisomerase I-mediated DNA cleavage. |
In vitro | There is synergism between Coralyne and Paclitaxel on proliferation and migration of breast cancer cell lines. This study also showed that combinational drug treatment decreased the expression of ki-67 and there was an increase in pro apoptotic factor Bax with decreased in expression of anti-apoptotic factor Bcl-2 in breast cancer cell lines with negligible effect on normal breast cell line[2]. |
分子量 | 399.87 |
分子式 | C22H22ClNO4 |
CAS No. | 38989-38-7 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 1.5 mg/mL (3.75 mM)
H2O: 3 mg/mL (7.50 mM)
You can also refer to dose conversion for different animals. 詳細
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Coralyne chloride 38989-38-7 DNA Damage/DNA Repair Topoisomerase Coralyne Chloride cancer inhibit neurodrug Inhibitor Coralyne Antileukemic protoberberine topoisomerase I inhibitor