Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DC_AC50 is a dual inhibitor of Atox1 and CCS (copper chaperones). Inhibiting intracellular copper chaperones as a means of reducing/preventing acquired chemotherapy resistance.DC_AC50 binding to Atox1 and CCS and reducing cancer cell proliferation and tumour growth.
パッケージサイズ | 在庫状況 | 単価(税別) | |||
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2 mg | 在庫あり | ¥ 10,000 | |||
5 mg | 在庫あり | ¥ 16,000 | |||
10 mg | 在庫あり | ¥ 24,000 | |||
25 mg | 在庫あり | ¥ 45,500 | |||
50 mg | 在庫あり | ¥ 72,000 | |||
100 mg | 在庫あり | ¥ 107,500 | |||
1 mL * 10 mM (in DMSO) | 在庫あり | ¥ 17,500 |
説明 | DC_AC50 is a dual inhibitor of Atox1 and CCS (copper chaperones). Inhibiting intracellular copper chaperones as a means of reducing/preventing acquired chemotherapy resistance.DC_AC50 binding to Atox1 and CCS and reducing cancer cell proliferation and tumour growth. |
In vitro | DC_AC50 synergised with carboplatin in combination treatment of human and canine OSA cells to reduce cancer cell viability.?DC_AC50-treated cells were significantly less mitotically active, as demonstrated by decreased expression of phospho-histone H3 and cell cycle analysis.?DC_AC50 also potentiated carboplatin-induced apoptosis in OSA cells and decreased clonogenic survival.?Finally, DC_AC50 reduced the migratory ability of OSA cells.?These results justify further investigation into inhibiting intracellular copper chaperones as a means of reducing/preventing acquired chemotherapy resistance. |
分子量 | 424.26 |
分子式 | C17H12BrF2N3OS |
CAS No. | 497061-48-0 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 25 mg/mL (58.93 mM)
You can also refer to dose conversion for different animals. 詳細
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DC_AC50 497061-48-0 Apoptosis Others DC_AC-50 resistance osteosarcoma CCS copper chaperones Atox1 inhibit Chemotherapy Inhibitor inhibitor