Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Doxorubicin (Adriamycin) is a Topoisomerase II (Top2) inhibitor with antineoplastic activity.
ターゲット&IC50 | Topo I:0.8 μM (IC50), Topo II:2.67 μM (IC50) |
In vivo | In an experiment, mice with PC3 xenografts received injections of Doxorubicin at dosages of 2, 4, or 8 mg/kg, and tumor volume was monitored. The 2 mg/kg dose did not inhibit tumor growth, but doses of 4 mg/kg and 8 mg/kg initially delayed growth, significantly reducing c-FLIP levels in the tumors (p<0.05 on days 18 and 22)[3]. In a separate study with rats, treatments involved a single intraperitoneal injection of 10 mg/kg Doxorubicin, ten daily injections of 1 mg/kg, or five weekly injections of 2 mg/kg, resulting in an 80% mortality rate by day 28 for the first group, and on days 107 and 98 for the latter groups, respectively. Furthermore, fractional shortening—a measure of heart function—decreased by 30% in the first group at week 2, 55% in the second group at week 13, and 42% in the third group at week 13[4]. |
別名 | Hydroxydaunorubicin, Adriamycin |
分子量 | 543.52 |
分子式 | C27H29NO11 |
CAS No. | 23214-92-8 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
H2O: 50mg/mL
DMSO: 10 mM
You can also refer to dose conversion for different animals. 詳細
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Doxorubicin 23214-92-8 Chromatin/Epigenetic DNA Damage/DNA Repair PI3K/Akt/mTOR signaling Topoisomerase AMPK HIV Bacterial Hydroxydaunorubicin inhibit Antibiotic ADC Payload HBV Inhibitor AMP-activated protein kinase Hepatitis B virus Apoptosis Mitophagy Adriamycin Mitochondrial Autophagy Human immunodeficiency virus Autophagy ADC Cytotoxin inhibitor