Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Aldoxorubicin hydrochloride is an albumin-binding prodrug of Doxorubicin, a DNA topoisomerase II inhibitor. Aldoxorubicin hydrochloride is released from albumin under acidic conditions. Aldoxorubicin hydrochloride exhibits potent antitumor activities in various cancer cell lines and in murine tumor models.
説明 | Aldoxorubicin hydrochloride is an albumin-binding prodrug of Doxorubicin, a DNA topoisomerase II inhibitor. Aldoxorubicin hydrochloride is released from albumin under acidic conditions. Aldoxorubicin hydrochloride exhibits potent antitumor activities in various cancer cell lines and in murine tumor models. |
In vitro | Aldoxorubicin hydrochloride (0.27 to 2.16 μM) inhibits formation of blood vessel and reduces growth of multiple myeloma cell in a pH-dependent fashion[1]. |
In vivo | Aldoxorubicin hydrochloride (10.8 mg/kg, i.v.) significantly reduces tumor volumes and IgG levels by day 28, showing high tolerability with a 90% survival rate in mice with LAGκ-1A tumors [1]. It demonstrates a favorable safety profile at doses up to 260 mg/mL doxorubicin equivalents, effectively inducing tumor regression in breast cancer, small cell lung cancer, and sarcoma during a phase I study [2]. Additionally, it outperforms doxorubicin in murine renal cell carcinoma and breast carcinoma xenograft models [3]. |
別名 | Aldoxorubicin hydrochloride (1361644-26-9 Free base) |
分子量 | 787.21 |
分子式 | C37H43ClN4O13 |
CAS No. | 1361563-03-2 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 7.87 mg/mL (10 mM)
You can also refer to dose conversion for different animals. 詳細
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Aldoxorubicin hydrochloride 1361563-03-2 DNA Damage/DNA Repair Topoisomerase Aldoxorubicin hydrochloride (1361644-26-9 Free base) Aldoxorubicin Hydrochloride 1361644-26-9 Free base 1361644-26-9 Inhibitor inhibitor inhibit