Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Doxycycline hydrochloride (Hyclate) is a synthetic tetracycline derivative with similar antimicrobial activity.
In vitro | In Wistar rats, daily administration of Doxycycline (25 mg) effectively inhibits the structural degradation of aortic elastin, diminishes the activity of matrix metalloproteinases MMP-2 and MMP-9 in the arterial wall, and consequently reduces the replication of smooth muscle cells in the intima. |
In vivo | Doxycycline (50 μM) downregulates the expression of MMP-8 at both mRNA and protein levels in rheumatoid synovial fibroblasts and endothelial cells while completely inhibiting the degradation of type II collagen. Additionally, in corneal epithelial cells, doxycycline suppresses the increase in mRNA and protein levels of IL-1β induced by lipopolysaccharide. |
別名 | Doxylin, Vibramycin, Hyclate |
分子量 | 480.9 |
分子式 | C22H24N2O8·HCl |
CAS No. | 10592-13-9 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 10 mM
You can also refer to dose conversion for different animals. 詳細
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Doxycycline hydrochloride 10592-13-9 Microbiology/Virology Proteases/Proteasome MMP Antibacterial Antibiotic Inhibitor Matrix metalloproteinases Doxylin LNT-229 G55 inhibit 293T U343 Doxycycline anti-proliferative activity Doxycycline Hydrochloride MCF 12A Bacterial antibacterial activity Vibramycin Hyclate SVG inhibitor