Powder: -20°C for 3 years | In solvent: -80°C for 1 year
E 0747 (E0747) is a new antiarrhythmic compound that inhibits arrhythmias by inhibiting Na channels in cardiac cells.
パッケージサイズ | 在庫状況 | 単価(税別) |
---|---|---|
1 mg | 在庫あり | ¥ 67,500 |
2 mg | 在庫あり | ¥ 100,000 |
5 mg | 在庫あり | ¥ 166,000 |
10 mg | 在庫あり | ¥ 226,500 |
25 mg | 在庫あり | ¥ 349,000 |
説明 | E 0747 (E0747) is a new antiarrhythmic compound that inhibits arrhythmias by inhibiting Na channels in cardiac cells. |
In vivo | Intravenous injection of 3 mg/kg of E-0747 through a femoral vein cannula over a period of seconds using four canine models of ventricular arrhythmia: digitalis, sedation, arrhythmia, and heart failure concluded that E-0747 inhibits arrhythmia by inhibiting Na channels in cardiomyocytes[1];At a frequency of 1 Hz and a concentration higher than 3 X 10(-7) M, E-0747 decreased the maximum rate of rise (Vmax) of the action potential of Purkinje fibers in porcine heart, whereas the resting membrane potential was unchanged, and E-0747 inhibited Vmax in a rate-dependent manner.The inhibition was about 50% at a concentration of 3 X 10(-6) M with a stimulus of 3.3 Hz.[4]. |
別名 | E 747, L 29065, E0747, E-0747 |
分子量 | 421.92 |
分子式 | C21H28ClN3O4 |
CAS No. | 99599-78-7 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
You can also refer to dose conversion for different animals. 詳細
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E 0747 99599-78-7 Membrane transporter/Ion channel Sodium Channel E 747 L 29065 E0747 E-0747 Inhibitor inhibitor inhibit