Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Rufinamide (E 2080), a triazole derivative, is used as voltage-gated sodium channel blocker for the treatment of seizure disorders.
説明 | Rufinamide (E 2080), a triazole derivative, is used as voltage-gated sodium channel blocker for the treatment of seizure disorders. |
In vitro | Rufinamide effectively suppresses maximal electroshock (MES)-induced tonic convulsions in mice (ED50 = 23.9 mg/kg) and rats (ED50 = 6.1 mg/kg). Additionally, Rufinamide inhibits pentylenetetrazol-(ED 50=54.0), bicuculline-(ED 50=50.5), and picrotoxin (ED 50=76.3 mg/kg) provoked clonic seizures in mice. Furthermore, it prevents pentylenetetrazole-induced epileptic seizures in mice at an effective dose of 45.8 mg/kg (ED50). |
In vivo | Rufinamide inhibits sodium-dependent action potentials in neurons, potentially exhibiting membrane stabilizing effects. |
別名 | CGP 33101, E 2080, RUF 331 |
分子量 | 238.19 |
分子式 | C10H8F2N4O |
CAS No. | 106308-44-5 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 16.67 mg/mL (69.97 mM), Sonication is recommended.
Ethanol: < 1 mg/mL (insoluble or slightly soluble)
You can also refer to dose conversion for different animals. 詳細
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Rufinamide 106308-44-5 Membrane transporter/Ion channel Sodium Channel Inhibitor CGP33101 CGP-33101 RUF-331 RUF331 CGP 33101 E 2080 E2080 inhibit RUF 331 E-2080 inhibitor