Powder: -20°C for 3 years | In solvent: -80°C for 1 year
E-5324 is potent cholesterol acyltransferase (ACAT) inhibitor (IC50s: 44 to 190 nM).
パッケージサイズ | 在庫状況 | 単価(税別) |
---|---|---|
25 mg | 約8-10 週間 | ¥ 452,500 |
50 mg | 約8-10 週間 | ¥ 592,500 |
100 mg | 約8-10 週間 | ¥ 780,500 |
ターゲット&IC50 | ACAT:44 to 190 nM |
In vivo | Treatment with E-5324 significantly reduces both the wet weight and protein content. A high dose of E-5324 (0.1%) notably decreases the surface involvement by 34% in the aortic arch and by 54% in the thoracic aorta. At the same concentration, it substantially lowers cholesteryl ester and total cholesterol levels in the aortic arch by 60% and 59%, respectively. Furthermore, this dosage markedly reduces ACAT activities in the aortic arch and thoracic aorta by 35% and 44%, respectively. The area under the cholesterol-time curves (AUC) for the duration of the study for control, 0.02% E-5324, and 0.1% E-5324 are 104985±4411, 106096±4476, and 105231±4348 mg×day/dL, respectively [2]. |
分子量 | 434.57 |
分子式 | C26H34N4O2 |
CAS No. | 141799-76-0 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
You can also refer to dose conversion for different animals. 詳細
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E-5324 141799-76-0 Others E5324 E 5324 Inhibitor inhibitor inhibit