Powder: -20°C for 3 years | In solvent: -80°C for 1 year
EMD534085 is an effective and selective mitotic kinesin-5 inhibitor (IC50: 8 nM).
パッケージサイズ | 在庫状況 | 単価(税別) |
---|---|---|
500 μg | 約 35 days | ¥ 22,500 |
1 mg | 約 35 days | ¥ 41,500 |
5 mg | 約 35 days | ¥ 181,000 |
10 mg | 約 35 days | ¥ 314,500 |
ターゲット&IC50 | Kinesin-5:8 nM |
In vivo | In a pharmacokinetic study of EMD 534085 conducted at a low dose in mice, average clearance was observed at 1.8 L/h/kg, with a volume of distribution of 7.4 L/kg and a half-life approximately 2.5 hours. High dose experiments (>10 mg/kg) consistently demonstrated a bioavailability exceeding 50% in mice. Intraperitoneal administration of EMD 534085 resulted in significant systemic exposure, contributing to a notable reduction in tumor growth without inducing toxic side effects [1]. |
分子量 | 476.53 |
分子式 | C25H31F3N4O2 |
CAS No. | 858668-07-2 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 25 mg/mL (52.46 mM)
You can also refer to dose conversion for different animals. 詳細
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.
EMD534085 858668-07-2 Cytoskeletal Signaling Kinesin EMD-534085 EMD 534085 Inhibitor inhibitor inhibit