Powder: -20°C for 3 years | In solvent: -80°C for 1 year
ERDRP-0519 is an orally bioavailable small-molecule inhibitor of the Measles virus (MeV) polymerase. It effectively prevents measles disease in squirrel monkeys (Saimiri sciureus) and exhibits potent inhibition of morbilliviruses in the nanomolar range.
パッケージサイズ | 在庫状況 | 単価(税別) | |||
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1 mg | 在庫あり | ¥ 32,000 | |||
5 mg | 在庫あり | ¥ 80,000 | |||
10 mg | 在庫あり | ¥ 112,000 | |||
25 mg | 在庫あり | ¥ 180,500 | |||
50 mg | 在庫あり | ¥ 257,000 | |||
100 mg | 在庫あり | ¥ 340,000 | |||
1 mL * 10 mM (in DMSO) | 在庫あり | ¥ 88,000 |
説明 | ERDRP-0519 is an orally bioavailable small-molecule inhibitor of the Measles virus (MeV) polymerase. It effectively prevents measles disease in squirrel monkeys (Saimiri sciureus) and exhibits potent inhibition of morbilliviruses in the nanomolar range. |
In vitro | ERDRP-0519 exhibits potency against a panel of Measles virus (MeV) isolates with EC50s of 0.07- 0.3 µM[1]. ERDRP-0519 exhibits potency against MeV and related pathogens of the Morbillivirus genus, such as canine distemper virus (CDV)[3]. |
In vivo | A single-dose pharmacokinetic study was conducted in squirrel monkeys through oral administration of ERDRP-0519 at a dose of 50 mg/kg, with blood samples collected at seven predetermined time points following the dose. The peak serum concentrations of ERDRP-0519 were observed approximately 2 hours post-administration, reaching a maximum (Cmax) of 3.27 µM. |
別名 | ERDRP0519, ERDRP 0519 |
分子量 | 529.58 |
分子式 | C23H30F3N5O4S |
CAS No. | 1374006-96-8 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 90 mg/mL (169.9 mM), Sonication is recommended.
You can also refer to dose conversion for different animals. 詳細
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.
ERDRP-0519 1374006-96-8 Immunology/Inflammation Antiviral ERDRP0519 ERDRP 0519 Inhibitor inhibitor inhibit