store at low temperature
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Epimedokoreanin B (EKB), an isoprenylated flavonoid isolated from Korean Epimedium, exhibited anticancer activity in human non-small cell lung cancer (NSCLC) A549 and NCI-H292 cells.Epimedokoreanin B also possesses anti-inflammatory and antibacterial activities, and may have scavenging activity against DPPH radicals, inhibiting the proliferation of MCF-7 and HepG2 in a dose-dependent manner. Epimedokoreanin B also exhibits anti-inflammatory and antibacterial activity, with DPPH radical scavenging activity, and inhibits the proliferation of MCF-7 and HepG2 in a dose-dependent manner.Epimedokoreanin B significantly inhibits the formation of N (α)-(carboxymethyl)lysine (CML) and N (Ï)-(carboxymethyl)arginine (CMA), and prevents clinical complications of diabetes mellitus through the inhibition of advanced glycation end-products (AGEs).
パッケージサイズ | 在庫状況 | 単価(税別) | |||
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サンプルについてお問い合わせ | |||||
1 mg | 在庫あり | ¥ 45,000 | |||
5 mg | 在庫あり | ¥ 114,000 | |||
10 mg | 在庫あり | ¥ 166,000 | |||
1 mL * 10 mM (in DMSO) | 在庫あり | ¥ 229,000 |
説明 | Epimedokoreanin B (EKB), an isoprenylated flavonoid isolated from Korean Epimedium, exhibited anticancer activity in human non-small cell lung cancer (NSCLC) A549 and NCI-H292 cells.Epimedokoreanin B also possesses anti-inflammatory and antibacterial activities, and may have scavenging activity against DPPH radicals, inhibiting the proliferation of MCF-7 and HepG2 in a dose-dependent manner. Epimedokoreanin B also exhibits anti-inflammatory and antibacterial activity, with DPPH radical scavenging activity, and inhibits the proliferation of MCF-7 and HepG2 in a dose-dependent manner.Epimedokoreanin B significantly inhibits the formation of N (α)-(carboxymethyl)lysine (CML) and N (Ï)-(carboxymethyl)arginine (CMA), and prevents clinical complications of diabetes mellitus through the inhibition of advanced glycation end-products (AGEs). |
In vitro |
Epimedokoreanin B (compound6) (3.13-25 μM; 48 h) showed significant inhibitory effects on the proliferation of lung cancer cells A549, Calu1, and H1299. Epimedokoreanin B is non-toxic to human bronchial epithelial cells BEAS-2B.[1] Epimedokoreanin B (5 μM; 24 h) inhibits CD163 expression and IL-10 production, a known M2 marker, indicating that Epimedokoreanin B inhibits M2 polarization in human monocyte-derived macrophages (HMDM). Epimedokoreanin B inhibits STAT3 activation in HMDMs.[4] Epimedokoreanin B treatment inhibits cell proliferation and migration accompanied by cytoplasmic vacuolation in A549 and NCI-H292 cells. Autophagosome accumulation accompanied by blockage of autophagic flux was observed in Epimedokoreanin B-treated cells, consistent with the occurrence of endoplasmic reticulum stress.[2] |
植物由来 |
分子量 | 422.47 |
分子式 | C25H26O6 |
CAS No. | 161068-53-7 |
store at low temperature
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
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Epimedokoreanin B 161068-53-7 Apoptosis Microbiology/Virology Others Antibacterial Inhibitor inhibitor inhibit