Powder: -20°C for 3 years | In solvent: -80°C for 1 year
LDCA is a double-hit metabolic regulator that exhibits potent anti-proliferative activity. lDCA competitively inhibits LDH-A enzyme activity, alters mitochondrial hyperpolarization and simultaneously subverts apoptosis. lDCA has a pronounced effect in cancer cells and does not show toxicity.
パッケージサイズ | 在庫状況 | 単価(税別) | |||
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サンプルについてお問い合わせ | |||||
5 mg | 在庫あり | ¥ 15,000 | |||
10 mg | 在庫あり | ¥ 22,500 | |||
25 mg | 在庫あり | ¥ 45,500 | |||
50 mg | 在庫あり | ¥ 75,500 | |||
100 mg | 在庫あり | ¥ 122,500 | |||
500 mg | 在庫あり | ¥ 264,000 |
説明 | LDCA is a double-hit metabolic regulator that exhibits potent anti-proliferative activity. lDCA competitively inhibits LDH-A enzyme activity, alters mitochondrial hyperpolarization and simultaneously subverts apoptosis. lDCA has a pronounced effect in cancer cells and does not show toxicity. |
In vitro | LDCA (2-100 μM ; 16-72 h) and Doxorubicin combination synergistically inhibit tumor progression. 15% death when cells were exposed to LDCA individually and caused 40% melanoma cell death combination synergistically with doxorubicin.[1] |
In vivo | LDA (2 mg/kg, iv., 6 days ; once) combination with doxorubicin effectively alleviated tumor necrosis in mice and significantly improved their survival ability, leading to sustained limitations in tumor growth kinetics.[1] |
分子量 | 256.49 |
分子式 | C8H5Cl3FNO |
CAS No. | 349106-80-5 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 90.0 mg/mL (350.9 mM ), Sonication and heating to 60℃ are recommended.
You can also refer to dose conversion for different animals. 詳細
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LDCA 349106-80-5 Apoptosis Metabolism Dehydrogenase Inhibitor inhibitor inhibit