Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Flosulide is an effective selective COX-2 inhibitor for the treatment of inflammatory diseases.
パッケージサイズ | 在庫状況 | 単価(税別) |
---|---|---|
25 mg | 約6-8 週間 | ¥ 383,500 |
50 mg | 約6-8 週間 | ¥ 500,500 |
100 mg | 約6-8 週間 | ¥ 643,000 |
In vitro | Flosulide entirely inhibits the mitotic activity of OSC-2 cells while having no impact on the mitotic activity of OSC-1 cells. Additionally, Flosulide demonstrates a concentration-dependent effect on the OSC-2 cell line by fully suppressing PGE2 production across a range of 1 nM to 100 μM; however, it does not affect prostaglandin (PG) synthesis in OSC-1 cells. |
In vivo | In normovolemic rats, flosulide enhances renal plasma flow (RPF) and glomerular filtration rate (GFR), while in hypovolemic rats, it reduces these measures at dosages between 5-25 mg/kg. At a dosage of 5 mg/kg, flosulide lowers 6-keto-PGF1alpha, and at 25 mg/kg or following 10 mg/kg of indomethacin, it leads to a decrease in both 6-keto-PGF1alpha and TXB2[1]. Furthermore, flosulide at 0.75 mg/day notably decreases proteinuria compared to aspirin treatment and results in significantly higher plasma protein and albumin levels than those observed in aspirin-treated rats[3]. |
別名 | ZK 38997, CGP 28238 |
分子量 | 353.34 |
分子式 | C16H13F2NO4S |
CAS No. | 80937-31-1 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
You can also refer to dose conversion for different animals. 詳細
bottom
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.
Flosulide 80937-31-1 Immunology/Inflammation Neuroscience COX ZK-38997 ZK38997 CGP-28238 ZK 38997 CGP 28238 CGP28238 Inhibitor inhibitor inhibit