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カタログ番号 | 製品名 | 別名 | ターゲット |
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T10033 | COX-2-IN-1 | COX | |
COX-2-IN-1 is a potent and selective COX-2 inhibitor (IC50: 3.9 μM). | |||
T10032 | COX-2-IN-2 | COX | |
COX-2-IN-2, a selective inducible COX2 inhibitor, exhibits potent inhibition with an IC50 of 0.24 μM. Meanwhile, COX-2-IN-1 functions as an anti-inflammatory agent, demonstrating both anti-inflammatory and analgesic acti... | |||
T77618 | COX-2-IN-34 | COX | |
COX-2-IN-34 is a selective, orally potent COX-2 inhibitor that shows anti-inflammatory activity without gastric ulcer toxicity during experiments in mice. | |||
T62061 | COX-2-IN-6 | COX , Prostaglandin Receptor | |
COX-2-IN-6 is a potent, selective, and orally available cyclooxygenase-2 (COX-2) inhibitor with an IC50 of 0.84 μM and a Ki of 69 nM.COX-2-IN-6 inhibits COX-2-driven PGE2 synthesis with an IC50 of 0.60 μM.COX-2-IN-6 is u... | |||
T6574 | Lumiracoxib | Prexige,COX-189 | COX |
Lumiracoxib (Prexige) is a novel, selective COX-2 inhibitor with IC50 and Ki of 0.14 μM and 0.06 μM, exhibits 515-fold selectivity over COX-1. Phase 4. | |||
T7207 | FK 3311 | FK-3311,COX-2 Inhibitor V | COX |
FK 3311 (COX-2 Inhibitor V) is a cell permeable and orally available sulfonanilide that acts as a COX-2 inhibitor and non-steroidal anti-inflammatory drug (NSAID) | |||
T13263 | COX/5-LO-IN-1 | Atreleuton analog | COX |
COX/5-LO-IN-1 is a cyclooxygenase and 5-lipoxygenase (5-LO) inhibitor, and used for inflammatory and allergic disease states. | |||
T79760 | COX-2-IN-35 | COX | |
COX-2-IN-35 (compound 7) is a selective inhibitor of COX-2, demonstrating anti-inflammatory activity, with an inhibitory concentration (IC 50) of 4.37 nM [1]. | |||
T62175 | COX-2-IN-8 | ||
COX-2-IN-8 (Compound 6a) is a potent, selective, orally active COX-2 inhibitor (IC50: 6.585 μM) with a higher COX-2 selectivity than Celecoxib. | |||
T61264 | COX-2-IN-19 | ||
COX-2-IN-19 (Compound 24) is a highly potent inhibitor of cyclooxygenase-2 (COX-2) with an IC50 value of 1.76 μM. Notably, COX-2-IN-19 exhibits robust in vivo anti-inflammatory activity [1]. | |||
T61714 | COX-2-IN-13 | ||
COX-2-IN-13 (compound 13e) is a highly potent and selective inhibitor of COX-2, demonstrating a remarkable IC50 value of 0.98 μM. It exhibits strong anti-inflammatory activity and has shown favorable results in vivo acut... | |||
T78706 | COX-2-IN-31 | COX | |
COX-2-IN-31 (compound 7b) is an orally active dual inhibitor targeting COX-2 (IC50=60 nM) and 5-LOX (IC50=1.9 μM). Additionally, it inhibits the activity of transmembrane hCA IX (Ki=48.9 nM) and hCA XII (Ki=5.8 nM). This... | |||
T78705 | COX-2-IN-30 | COX | |
COX-2-IN-30, a benzenesulfonamide derivative, is an orally active, dual inhibitor of cyclooxygenase-2 (COX-2; IC50 = 49 nM) and cyclooxygenase-1 (COX-1; IC50 = 10.4 μM), as well as 5-lipoxygenase (5-LOX; IC50 = 2.4 μM). ... | |||
T63480 | COX-2-IN-26 | ||
COX-2-IN-26 is a potent, orally active, selective COX-2 inhibitor that acts on COX-1 (IC50: 10.61 μM), COX-2 (IC50: 0.067 μM), and 15-LOX (IC50: 1.96 μM).COX-2-IN-26 is anti-inflammatory and has a gastrointestinal safety... | |||
T63348 | COX-2-IN-23 | ||
COX-2-IN-23 is a selective inhibitor of COX-2, with IC50 values of 0.28 and 20.14 μM for COX-2 and COX-1, respectively.COX-2-IN-23 exhibits anti-inflammatory effects as well as low ulcerogenic effects. | |||
T61711 | COX-2-IN-14 | ||
COX-2-IN-14 (compound 2a) is a highly potent and selective inhibitor of COX-2 (cyclooxygenase-2), with strong binding affinity at the active site of COX-2 co-crystal. Demonstrating remarkable in vivo anti-inflammatory ac... | |||
T60978 | COX-2-IN-7 | ||
COX-2-IN-7 (compound 4a) is a potent, selective, and orally active COX-2 inhibitor which is higher selectivity than Celecoxib with an IC 50 value of 6.585 uM. COX-2-IN-7 has good anti-inflammatory and low ulcerogenic act... | |||
T61821 | COX-2-IN-16 | ||
COX-2-IN-16 (compound 2b) is a potent, selective, and orally active inhibitor of cyclooxygenase-2 (COX-2) with an IC50 value of 102 μM. It effectively reduces nitric oxide (NO) production and demonstrates anti-inflammato... | |||
T78754 | COX-2-IN-33 | COX | |
COX-2-IN-33 (compound 5f) is a selective COX-2 inhibitor with an IC50 value of 45.5 nM and exhibits potential as an anti-inflammatory agent. It effectively suppresses pro-inflammatory cytokine production in vivo while ma... | |||
T62350 | XO/COX/LOX-IN-1 | ||
XO/COX/LOX-IN-1 is a potent inhibitor of xanthine oxidase/cyclooxygenase/lipoxygenase XO/COX/LOX. XO/COX/LOX-IN-1 can be used in the study of inflammatory, cancer and metabolic diseases. | |||
T79594 | COX-1/2-IN-5 | COX | |
COX-1/2-IN-5 (compound 2a) functions as a dual inhibitor of COX1/2, demonstrating inhibitory concentrations (IC50) of 2.650 μM and 0.958 μM, respectively, and exhibits anticancer activity by inhibiting liver cancer HepG2... | |||
T64109 | COX-2-IN-28 | ||
COX-2-IN-28 is a potent and selective COX-2 inhibitor capable of acting on COX-2 (IC50: 0.054 μM), 15-LOX (IC50: 2.14 μM) and COX-1 (IC50: 13.21 μM). | |||
T63943 | COX-2-IN-10 | ||
COX-2-IN-10 is a potent inhibitor of COX-2. COX-2-IN-10 exhibits inhibitory effects on the production of IL-6, TNF-α and IL-1β. COX-2-IN-10 inhibits PGE2 production in a concentration-dependent manner with an IC50 value ... | |||
T60457 | COX-2-IN-11 | ||
COX-2-IN-11 (compound 7b2) is a potent and selective COX-2 inhibitor. COX-2-IN-11 has the potential in inflammation disease research[1]. | |||
T63646 | COX-2-IN-9 | ||
COX-2-IN-9 is a selective, potent, orally active COX-2 inhibitor (IC50: 10.17 μM).COX-2-IN-9 has a higher COX-2 selectivity than Celecoxib.COX-2-IN-9 exhibits good in vivo anti-inflammatory activity and low ulcerogenic e... | |||
T62259 | COX-2-IN-21 | ||
COX-2-IN-21 (Compound 5c) is an orally active, selective COX-2 inhibitor (IC50: 0.039 μM). COX-2-IN-21 has good anti-inflammatory potential. | |||
T63336 | COX-2-IN-29 | ||
COX-2-IN-29 is a selective inhibitor of orally active COX-2 (IC50: 0.005 μM). | |||
T61760 | COX-2-IN-18 | ||
COX-2-IN-18 (Compound 3) is a highly effective COX-2 inhibitor with strong inhibitory activity against COX-2 (IC 50 = 0.775 μM). Its potency is comparable to the reference drug Celecoxib (IC 50 = 0.153 μM). This compound... | |||
T60566 | COX-2-IN-12 | ||
COX-2-IN-12 (compound 3b) is a potent and selective COX-2 inhibitor with an IC 50 of 19.98 μM. COX-2-IN-12 is an anti-inflammatory agent that shows safety in-vivo acute toxicity studies [1]. | |||
T64063 | COX-2-IN-24 | ||
COX-2-IN-24 is an orally active COX-2 inhibitor (IC50: 0.17 μM) with anti-inflammatory and hypo-ulcerogenic effects. | |||
T60464 | COX-2-IN-20 | ||
COX-2-IN-20 (Compound 5d) is a selective and orally active inhibitor of COX-2 (IC 50 = 17.9 nM) with anti-inflammatory activity [1]. | |||
T62142 | COX-2-IN-17 | ||
COX-2-IN-17 is a potent, blood-brain barrier permeable COX-2 (cyclooxygenase-2) inhibitor (IC50: 0.02 μM) with anti-inflammatory and analgesic activity. | |||
T79130 | COX-2-IN-32 | NF-κB | |
COX-2-IN-32 (Compound 2f) is a dual inhibitor of iNOS and COX-2, known to downregulate NF-κB expression. Demonstrating anti-inflammatory properties, it impedes NO production in LPS-induced RAW264.7 macrophages with an IC... | |||
T63215 | COX-2-IN-22 | ||
COX-2-IN-22 is a COX-2 inhibitor (IC50: 8.6 μM) that can cross the blood-brain barrier and also exhibits inhibitory effects on AChE (IC50: 2.8 μM), BChE (IC50: 6.3 μM), β-Secretase (IC50: 15.3 μM), LOX-5 (IC50: 13.9 μM) ... | |||
T60992 | COX-1/2-IN-3 | ||
COX-1/2-IN-3 (Compound 7a) is a dual inhibitor of COX-1 and COX-2. COX-1/2-IN-3 has anti-inflammatory activity with low toxicity [1]. | |||
T60630 | COX/5-LOX-IN-1 | ||
COX/5-LOX-IN-1 (compound 6b) is a potent COX/5-LOX dual inhibitor with the potential for inflammation diseases research. COX/5-LOX-IN-1 has IC50s of 1.07, 0.55, and 0.28 μM for COX-1, COX-2, and 5-LOX enzyme, respectivel... | |||
T62103 | COX-2/PI3K-IN-1 | ||
COX-2/PI3K-IN-1 (compound 5d) is a potent inhibitor of PI3K (IC50: 1.14 nM). COX-2/PI3K-IN-1 is a selective inhibitor of COX-2 (Ki: 3.24 nM). | |||
T60769 | COX-2/PI3K-IN-2 | ||
COX-2/PI3K-IN-2 (compound 5f) has properties of anti-inflammatory and anti-cancer. COX-2/PI3K-IN-2 is a selective inhibitor of COX-2 (Ki = 3.02 nM) as well as a potent inhibitor of PI3K (IC 50 = 2.78 nM) [1]. | |||
T61352 | COX-2/5-LOX-IN-3 | ||
COX-2/5-LOX-IN-3 (compound 5b) is a powerful and dual inhibitor of COX-2 and 5-LOX, with IC50 values of 45.73 μM, 5.45 μM, and 4.33 μM for COX-1, COX-2, and 5-LOX, respectively. This compound, COX-2/5-LOX-IN-3, shows pro... | |||
T62998 | COX-2/15-LOX-IN-1 | ||
COX-2/15-LOX-IN-1 (Compound 14) is a COX-2 and 15-lipoxygenase (15-LOX) inhibitor that acts on COX-1 (IC50: 10.65 μM), COX-2 (IC50: 0.075 μM) and 15-LOX (IC50: 2.98 μM). 25 has an anti-inflammatory effect. | |||
T61939 | Topo I/COX-2-IN-1 | ||
Topo I/COX-2-IN-1 (1H-30) is a potent Topo I/COX-2 inhibitor with the IC50 of 0.24 μM and 4.42 μM for COX-2 and Topo I, respectively. Topo I/COX-2-IN-1 induces apoptosis and inhibits migration of cancer cells, shows anti... | |||
T62241 | Topo I/COX-2-IN-2 | ||
Topo I/COX-2-IN-2 (Compound W10) is a potent dual Topo I (IC50: 0.90 μM) and COX-2 (IC50: 2.31 μM) inhibitor.Topo I/COX-2-IN-2 induces apoptosis in cancer cells using the mitochondrial pathway. | |||
T79360 | COX-2/15-LOX-IN-2 | Lipoxygenase | |
COX-2/15-LOX-IN-2 is a potent inhibitor of both COX-2 and 15-LOX, demonstrating IC50 values of 0.065 μM for COX-2 and 1.86 μM for 15-LOX. Additionally, it exhibits significant antioxidant activity [1]. | |||
T61196 | COX-1/2-IN-1 | ||
COX-1/2-IN-2, a potent inhibitor of both COX-1 and COX-2, demonstrates significant inhibitory activity, with IC50 values of 13.9 ± 3.21 μM for COX-1 and 6.4 ± 0.74 μM for COX-2, respectively [1]. | |||
T61865 | COX-1/2-IN-2 | ||
COX-1/2-IN-2 is a potent inhibitor of both COX-1 and COX-2, displaying significant inhibitory effects with IC50 values of 9.7 ± 0.09 μM for COX-1 and 4.6 ± 1.45 μM for COX-2, respectively [1]. | |||
T79592 | COX-1/2-IN-4 | COX | |
COX-1/2-IN-4 (compound 2b) is a dual COX-1 and COX-2 inhibitor with respective IC50 values of 0.239 μM for COX-1 and 0.191 μM for COX-2. Additionally, it demonstrates moderate anticancer activity, exhibiting IC50 values ... | |||
T63398 | COX-2/sEH-IN-1 | ||
COX-2/sEH-IN-1 is an orally active dual inhibitor of COX-2 (IC50: 1.24 μM) and sEH (IC50: 0.40 μM), a soluble epoxide hydrolase. COX-2/sEH-IN-1 increases anti-inflammatory effects and significantly reduces cardiovascular... | |||
T60403 | COX-2/NO-IN-1 | ||
COX-2/NO-IN-1 is an orally active nitric oxide synthase (iNOS) and NO ( IC 50 of 3.52 μM) inhibitor as well as suppresses the expression of COX-2. COX-2/NO-IN-1 has anti-inflammatory effects and reduces pathological dama... | |||
T61910 | COX-2/5-LOX-IN-2 | ||
COX-2/5-LOX-IN-2 is a benzothiophen-2-ylpyrazole carboxylic acid derivative. COX-2/5-LOX-IN-2 (5b) inhibited both COX-2 and 5-LOX. The IC50s of COX-2/5-LOX-IN-2 inhibiting COX-1, COX-2 and 5-LOX were 5.40, 0.01 and 1.78 ... | |||
T79361 | COX-2/15-LOX-IN-3 | Lipoxygenase | |
COX-2/15-LOX-IN-3 (compound 5k) serves as a dual inhibitor for COX-2 and 15-LOX, demonstrating inhibitory concentrations (IC50) of 0.075 μM and 1.97 μM, respectively. This compound effectively suppresses LPS-induced cell... |
カタログ番号 | 製品名 | 別名 | ターゲット |
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T4S0590 | Columbin | Phospholipase , COX , Parasite | |
1. Columbin has anti-inflammatory activity. 2. Columbin has chemopreventive ability against human colon cancer. 3. Columbin inhibits PLA2 hydrolysis of ghost RBC in a dose-dependent fashion. | |||
T6S0077 | Byakangelicol | COX | |
1. Byakangelicol may inhibit P-gp expressed at the BBB even under in vivo conditions. 2. Byakangelicol can inhibit IL-1beta-induced PGE2 release in A549 cells; this inhibition may be mediated by suppression of COX-2 expr... | |||
TN1723 | Hamaudol | COX | |
Hamaudol is a chromone isolated from Saposhnikovia divaricata,has analgesic and anti-inflammary activities, it showed inhibitory activity on COX-1 and COX-2 activities with values of 0.30, 0.57 mM, respectively. | |||
T6S0413 | Pectolinarigenin | Pectolinaringenin | Others , Lipoxygenase , COX |
1. Pectolinarigenin (Pectolinaringenin) exhibits hepatoprotective activity mainly via SOD antioxidant mechanism. 2. Pectolinarigenin possesses anti-inflammatory activity and that they may inhibit eicosanoid formation in ... | |||
T3883 | Roburic acid | COX | |
Roburic acid and phenethyl-trans-ferulate inhibit COX-1 and COX-2. | |||
TQ0288 | Hexahydrocurcumin | Reactive Oxygen Species , ROS , COX | |
Hexahydrocurcumin is a selective, orally active COX-2 inhibitor and inactive against COX-1. | |||
T3824 | Jaceosidin | Apoptosis , BCL , COX , UGT | |
Jaceosidin has anti-oxidative activity. Jaceosidin has anti-inflammatory activity, also a microglial inhibitor with anti-neuroinflammation activity. aceosidin has anticancer activity, modulates the ERK/ATM/Chk1/2 pathway... | |||
T3399 | Psoralidin | Others , Estrogen/progestogen Receptor , Reactive Oxygen Species , Lipoxygenase , Gamma-secretase , Akt , COX , Antibacterial | |
Psoralidin inhibits Akt phosphorylation and phosphatidylinositol 3-kinase activation and transcriptionally. Psoralidin possesses anticancer and chemopreventive properties. | |||
T6S2023 | Harpagoside | Others , COX , NO Synthase | |
1. Harpagoside has anti-inflammatory activity. 2. Harpagoside at 3 mM concentration, shows moderate inhibition of seed germination. 3. Harpagoside can inhibit lipopolysaccharide-induced mRNA levels and protein expression... | |||
TN2139 | Regaloside B | NOS , COX , NO Synthase | |
Regaloside B, a phenylpropanoid isolated from Lilium longiflorum, exhibits anti-inflammatory activity by inhibiting the expression of iNOS (inducible nitric oxide synthase) and COX-2 (cyclooxygenase-2). | |||
T5758 | Sphondin | COX , Prostaglandin Receptor | |
Sphondin has anticonvulsant, anti-inflammatory, and anti-proliferative activities, it possessed an inhibitory effect on IL-1beta-induced increase in the level of COX-2 protein and PGE(2) release in A549 cells. | |||
TQ0180 | Chebulagic acid | SARS-CoV , Influenza Virus , Lipoxygenase , COX | |
Chebulagic acid, isolated from the Terminalia chebula Retz, is a COX-LOX dual inhibitor. | |||
T8240 | Cis-5-Dodecenoic Acid | Others | |
Cis-5-Dodecenoic Acid is a monounsaturated fatty acid that has a C12 chain as a backbone and a cis double bond at the C5 position. | |||
T3877 | Esculentoside A | NF-κB , COX | |
Esculentoside A can suppress inflammatory responses in LPS-induced ALI through inhibition of the NF-κB and mitogen-activated protein kinase signaling pathways. Esculentoside A may be useful for the treatment of autoimmun... | |||
T3747 | Syringaldehyde | Syringic aldehyde,Springaldehyde | COX |
syringaldehyde is a polyphenolic compound belonging to the group of flavonoids and is found in different plant species like Manihot esculenta and Magnolia officinalis. Syringaldehyde moderately inhibits COX-2 activity wi... | |||
T5S0045 | Isofraxidin | 6,8-Dimethoxyumbelliferone,Phytodolor | MMP , ERK , p38 MAPK , TLR , COX |
1. Isofraxidin (Phytodolor) protects leukemia cells from radiation-induced apoptosis via ROS/mitochondria pathway in a p53-independent manner. 2. Isofraxidin has a protective effect against LPS-induced ALI, and the prote... | |||
T8255 | (±)-Catechin | (±)-Catechin hydrate | ROS , COX |
(±)-Catechin ((±)-Catechin hydrate) hydrate is a natural product,has antioxidant activity and is effective in reducing oxidative stress. | |||
TN3500 | Beta-Amyrone | β-Amyron | COX , AChR , PPAR , Antifection |
beta-Amyrone (β-Amyron) has antifungal activity against Chikungunya virus replication with an EC50 of 86 uM. beta-Amyrone has anti-inflammatory activity through inhibiting the expression of COX-2. beta-Amyrone exhibits a... | |||
T2972 | Rutaecarpine | Rutacarpine,Rhetine,Rutecarpine | COX |
Rutaecarpine (Rhetine) is an inhibitor of COX-2 with IC50 of 0.28 μM. | |||
T7052 | Gnetol | Tyrosinase , COX , HDAC , AChR | |
Gnetol competitivity inhibits butyrylcholinesterase (IC50: 1.3 uM). Gnetol has a strong inhibitory effect on murine tyrosinase activity. Gnetol significantly suppresses melanin biosynthesis in murine B16 melanoma cells. ... | |||
T6S1572 | Sauchinone | ERK , p38 MAPK , NF-κB | |
1. Sauchinone is a useful adjunctive treatment for bacterial infection. 2. Sauchinone, an active lignan found in Saururus chinensis, to regulate the activation of HSCs, to prevent liver fibrosis, and to inhibit oxidative... | |||
T2826 | Asaraldehyde | Asarylaldehyde,2,4,5-trimethoxy-Benzaldehyde,Asaronaldehyde | COX |
Asaraldehyde (2,4,5-trimethoxy-Benzaldehyde), a natural COX-2 inhibitor, exhibits 17-fold selectivity than COX-1. | |||
T4643 | TFAP | N-(5-Aminopyridin-2-yl)-4-(trifluoromethyl)benzamide | COX , Endogenous Metabolite |
TFAP (N-(5-Aminopyridin-2-yl)-4-(trifluoromethyl)benzamide) is a selective cyclooxygenase-1 (COX-1) inhibitor | |||
T2778 | (+)-Catechin Hydrate | Antioxidant , COX | |
(+)-Catechin Hydrate is an antioxidant flavonoid of plant origin; a free radical scavenger, preventing free radical-mediated damage in a variety of biological systems. | |||
T5431 | [10]-Shogaol | 10-Shogaol | Antioxidant , COX |
[10]-Shogaol (10-Shogaol) is an extract from ginger displaying antioxidant activity. It also may contain hypolipidemic and insulin-sensitizing effects. | |||
T5430 | [8]-Shogaol | 8-SHOGAOL | Apoptosis , COX |
[8]-Shogaol is a component of ginger and maintains anti-inflammatory activity as a cyclooxygenase-2 inhibitor. | |||
T3866 | Macelignan | Anwuligan,(+)-Anwulignan | Others , COX |
Macelignan (Anwuligan) is a lignan isolated from nutmeg with antimicrobial and anticariogenic activity against Streptococcus mutans and other streptococcus species. | |||
T0443 | Salicin | Salicoside,Salicine,D-(−)-Salicin | COX |
Salicin (Salicine), a phenol β-glycoside produced from willow bark, shows anti-inflammatory functions. | |||
T7113 | Paradol | 6-paradol,[6]-Gingerone | COX |
Paradol ([6]-Gingerone) is a pungent phenolic substance found in ginger and other Zingiberaceae plants, and exhibits a variety of biological activities including anti-cancer, anti-inflammatory, and anti-oxidative activit... | |||
T3342 | Xanthohumol | Apoptosis , Others , Influenza Virus , COX , Acyltransferase , HSV | |
Xanthohumol, also known as 2', 4, 4'-trihydroxy-6'-methoxy-3'-prenylchalcone or desmethylxanthohumol, is a member of the class of compounds known as 3-prenylated chalcones. It inhibits COX-1 and COX-2 activity and shows ... | |||
TQ0169 | Inulicin | 1-O-Acetylbritannilactone | FAK , NF-κB , COX , Src |
Inulicin (1-O-Acetylbritannilactone), an active compound isolated from Inula Britannica L, inhibits VEGF-mediated activation of Src and FAK. | |||
T0649 | Salicylic acid | 2-Hydroxybenzoic acid | Apoptosis , Mitophagy , COX , Endogenous Metabolite , Autophagy |
Salicylic acid (2-Hydroxybenzoic acid), a natural compound extracted from Willow bark, is an anti-inflammatory inhibitor of activity cyclooxygenase. | |||
T5759 | S-(+)-Marmesin | (+)-Marmesin,(S)-Marmesin,marmesin | Lipoxygenase , COX |
S-(+)-Marmesin (marmesin) is a coumarin originally isolated from the mature bark of A. marmelos,exhibiting COX-2/5-LOX dual inhibitory activity. | |||
T2856 | (-)-Epicatechin | L-Epicatechin,Epicatechin,(-)-Epicatechol | Ferroptosis , COX , Endogenous Metabolite |
(-)-Epicatechin (Epicatechin) is an inhibitor of cyclooxygenase-1 (COX-1), inhibiting the IL-1β-induced expression of iNOS by blocking the nuclear localization of the p65 subunit of NF-κB. | |||
T6S1543 | Dehydrodiisoeugenol | Others , NF-κB , COX , Antibacterial | |
1. Dehydrodiisoeugenol has anti-inflammatory activity. (1). Dehydrodiisoeugenol inhibited the expression of the COX-2 in RAW264.7 murine macrophages stimulated with LPS. (2). Dehydrodiisoeugenol inhibited LPS-stimulated ... | |||
T3744 | Veratric acid | Veratrumenoic acid,3,4-Dimethoxybenzoic acid | Reactive Oxygen Species , COX |
Veratric acid (3,4-Dimethoxybenzoic acid) is a simple benzoic acid derived from plants and fruits with anti-oxidant, anti-inflammation and blood pressure-lowering effects. | |||
T6S0722 | Isoorientin | Homoorientin,Luteolin-6-C-glucoside | Antioxidant , COX |
Isoorientin (Homoorientin) has antioxidant activity. | |||
T5727 | CAFESTOL | ERK , NF-κB , COX , PGE Synthase | |
CAFESTOL is a ERK inhibitor for AP-1-targeted activity against PGE2 production and the mRNA expression of cyclooxygenase (COX)-2 in LPS-activated RAW264.7 cells. Cafestol has strong inhibitory activity on PGE2 production... | |||
T1468 | Lornoxicam | Ro 13-9297,Chlortenoxicam,TS110 | COX , Endogenous Metabolite |
Lornoxicam (Chlortenoxicam) (chlortenoxicam) is a new nonsteroidal anti-inflammatory drug (NSAID) of the oxicam class with analgesic, anti-inflammatory, and antipyretic properties. Lornoxicam differs from other oxicam co... | |||
T3S0645 | N-trans-Feruloyltyramine | Feruloyltyramine,N-Feruloyltyramine,Moupinamide | Others , COX |
1. N-trans-Feruloyltyramine (Feruloyltyramine)(NTF) has hepatoprotective effect. 2. NTF has antioxidative activity against Aβ(1-42)-induced neuronal death. 3. NTF is likely to inhibit COX enzymes, thereby suppressing P-s... | |||
T2S2335 | Dehydroevodiamine | DHED | Others , NF-κB , COX , PGE Synthase , NO Synthase |
Dehydroevodiamine (DHED), a constituent of Evodia rutaecarpa, has various biological effects such as hypotensive, negative chronotropic, ion channel depressant, inhibition of nitric oxide production and cerebral blood fl... | |||
T6S1487 | Ginsenoside Rg5 | NF-κB , COX , IGF-1R | |
1. Ginsenoside Rg5 could be a beneficial agent for the treatment of Alzheimer's disease. 2. Ginsenoside Rg5 suppresses LPS-induced nitric oxide (NO) production and proinflammatory TNF-α secretion. 3. Ginsenoside Rg5 can ... | |||
T8293 | γ-Tocopherol | (+)-γ-Tocopherol | COX |
(+)-γ-Tocopherol ((+)-γ-Tocopherol) is one of the naturally occurring forms of Vitamin E. It is the most abundant Tocopherol in soybean and corn oils. | |||
TN1377 | α-Spinasterol | alpha-Spinasterol | COX , Antibacterial , TRP/TRPV Channel |
α-Spinasterol is a transient receptor potential vanilloid 1 (TRPV1) antagonist, has anti-inflammatory, antidepressant, antioxidant and antinociceptive effects. α-Spinasterol inhibits COX-1 andCOX-2 activities with IC50 v... | |||
T5S2360 | Corydaline | Corydalin,(+)-Corydaline | P450 , Virus Protease , Opioid Receptor , AChE |
1. Corydaline (Corydalin), an isoquinoline alkaloid, is one of the major active constituents in a new prokinetic botanical agent. 2. Corydaline promotes gastric emptying and small intestinal transit and facilitates gastr... | |||
T0822 | Catechin | Catechinic acid,D-Catechin,(+)-Catechin,Cianidanol,Catechuic acid | Apoptosis , Influenza Virus , COX , Endogenous Metabolite |
Catechin (Cianidanol) is a flavan-3-ol, a type of natural phenol and antioxidant. | |||
TN1373 | α-Humulene | Alpha-caryophyllene | TNF , NOS , COX |
α-Humulene (Alpha-caryophyllene) is extracted from S.officinalis essential oil.α-Humulene can inhibit tumor cell growth.α-Humulene also shows anti-inflammatory effects, probably by interfering with TNFalpha production an... | |||
T0877 | Gallic acid | 3,4,5-Trihydroxybenzoic acid,Gallate,Benzoic acid | Apoptosis , Ferroptosis , Reactive Oxygen Species , ROS , COX , Endogenous Metabolite |
Gallic acid (Benzoic acid) is found in almost all plants. Plants known for their high gallic acid content include gallnuts,grapes,tea,hops and oak bark. | |||
T0065 | Acetaminophen | 4-Acetamidophenol,4'-Hydroxyacetanilide,APAP,Paracetamol | COX , Endogenous Metabolite , Histone Acetyltransferase |
Acetaminophen (APAP) is a COX inhibitor that inhibits COX-1 and COX-2 (IC50=113.7/25.8 μM). Acetaminophen has antipyretic and analgesic activity as well as weak anti-inflammatory activity. | |||
T5681 | ETHYL CAFFEATE | ETHYL 3,4-DIHYDROXYCINNAMATE | NF-κB , COX , PGE Synthase , NO Synthase |
Ethyl Caffeate (ETHYL 3,4-DIHYDROXYCINNAMATE) suppressed the differentiation of naive CD4+ T cells into Th1 in vitro. Furthermore, Ethyl Caffeate intensely blocked the transcriptional expression in interferon-γ-related s... | |||
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カタログ番号 | 製品名 | Species | Expression System |
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TMPY-01736 | COX-2 Protein, Human, Recombinant (His) | Human | Baculovirus-Insect Cells |
PTGS2, also known as COX-2, is s component of Prostaglandin-endoperoxide synthase (PTGS). PTGS, also known as cyclooxygenase, is the key enzyme in prostaglandin biosynthesis, and acts both as a dioxygenase and as a perox... | |||
TMPY-04807 | Coxsackievirus A16 (Cox A16) (strain G-10) VP4 Protein (Fc) | CV | Baculovirus-Insect Cells |
Coxsackievirus A16 (Cox A16) (strain G-10) VP4 Protein (Fc) is expressed in Baculovirus-Insect Cells with Fc tag. The predicted molecular weight is 32.6 kDa. Accession number: AAA50478.1 | |||
TMPY-04908 | Coxsackievirus A16 (Cox A16) (strain G-10) VP1 Protein (Fc) | CV | Baculovirus-Insect Cells |
Coxsackievirus A16 (Cox A16) (strain G-10) VP1 Protein (Fc) is expressed in Baculovirus-Insect Cells with Fc tag. The predicted molecular weight is 59.5 kDa. Accession number: AAA50478.1 | |||
TMPH-01179 | COX4I1 Protein, Human, Recombinant (His & SUMO) | Human | E. coli |
COX4I1 Protein, Human, Recombinant (His & SUMO) is expressed in E. coli. | |||
TMPY-02481 | ACOX1 Protein, Human, Recombinant (His) | Human | Baculovirus-Insect Cells |
Peroxisomal acyl-coenzyme A oxidase 1(ACOX1 or AOX) is the first enzyme of the fatty acid beta-oxidation pathway and belongs to the Acyl-CoA oxidase family. Human liver peroxisomes contain two acyl-CoA oxidases, namely, ... | |||
TMPY-03511 | COX5B Protein, Human, Recombinant (His) | Human | E. coli |
Cytochrome C oxidase (COX) is the terminal enzyme of the mitochondrial respiratory chain. It is a multi-subunit enzyme complex that couples the transfer of electrons from cytochrome c to molecular oxygen and contribut... | |||
TMPH-02617 | COX5A Protein, Mouse, Recombinant (His & SUMO) | Mouse | E. coli |
Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase... | |||
TMPH-02825 | ACOX1 Protein, Mouse, Recombinant (Myc) | Mouse | E. coli |
Catalyzes the desaturation of acyl-CoAs to 2-trans-enoyl-CoAs. First enzyme of the fatty acid beta-oxidation pathway.; Shows highest activity against medium-chain fatty acyl-CoAs and activity decreases with increasing ch... | |||
TMPY-03752 | COX4NB Protein, Human, Recombinant (His) | Human | E. coli |
COX4NB Protein, Human, Recombinant (His) is expressed in E. coli with His tag. The predicted molecular weight is 25.6 kDa. Accession number: O43402 | |||
TMPH-01180 | COX5A Protein, Human, Recombinant (GST) | Human | E. coli |
COX5A Protein, Human, Recombinant (GST) is expressed in E. coli. | |||
TMPH-03639 | COX7A1 Protein, Trachypithecus cristatu, Recombinant (hFc) | Trachypithecus cristatus | HEK293 |
COX7A1 Protein, Trachypithecus cristatu, Recombinant (hFc) is expressed in HEK293. | |||
TMPJ-00778 | HER2/ERBB2 Protein, Human, Recombinant (His) | Human | Human Cells |
Human epidermal growth factor receptor 2 (HER2) is a type of membrane glycoprotein, and belongs to the epidermal growth factor (EGF) receptor family. HER2 plays a key role in development, cell proliferation and different... | |||
TMPY-02900 | IL-17A Protein, Mouse, Recombinant | Mouse | E. coli |
IL17, also known as IL17a, is a cytokine that belongs to the IL-17 family. Cytokines are proteinaceous signaling compounds that are major mediators of the immune response. They control many different cellular functions i... | |||
TMPY-02886 | IL-17A Protein, Human, Recombinant | Human | E. coli |
IL17, also known as IL17a, is a cytokine that belongs to the IL-17 family. Cytokines are proteinaceous signaling compounds that are major mediators of the immune response. They control many different cellular functions i... | |||
TMPJ-00704 | SCO1 Protein, Human, Recombinant (GST) | Human | E. coli |
Protein SCO1 Homolog, Mitochondrial (SCO1) is a member of the SCO1/2 family. SCO1 has a homodimer structure. SCO1 is located in mitochondrion and is highly expressed in muscle, heart, and brain. It is characterized by hi... | |||
TMPY-03658 | ETHE1 Protein, Human, Recombinant (His) | Human | E. coli |
ETHE1, also known as HSCO, is a sulfur dioxygenase that localizes within the mitochondrial matrix. ETHE1 probably plays an important role in metabolic homeostasis in mitochondria. It may also function as a nuclear-cytopl... | |||
TMPJ-00776 | HER2/ERBB2 Protein, Human, Recombinant (hFc & Avi), Biotinylated | Human | Human Cells |
Human epidermal growth factor receptor 2 (HER2) is a type of membrane glycoprotein, and belongs to the epidermal growth factor (EGF) receptor family. HER2 plays a key role in development, cell proliferation and different... | |||
TMPJ-00777 | HER2/ERBB2 Protein, Human, Recombinant (aa 23-652, hFc) | Human | Human Cells |
Human epidermal growth factor receptor 2 (HER2) is a type of membrane glycoprotein, and belongs to the epidermal growth factor (EGF) receptor family. HER2 plays a key role in development, cell proliferation and different... | |||
TMPY-04023 | BCCIP Protein, Human, Recombinant (His & GST) | Human | Baculovirus-Insect Cells |
BCCIP was originally identified as a BRCA2 and CDKN1A interacting protein that has been implicated in maintenance of genomic stability, cell cycle regulation, and microtubule dynamics. The secondary genetic alternations ... | |||
TMPY-00578 | BCCIP Protein, Human, Recombinant | Human | Baculovirus-Insect Cells |
BCCIP was originally identified as a BRCA2 and CDKN1A interacting protein that has been implicated in maintenance of genomic stability, cell cycle regulation, and microtubule dynamics. The secondary genetic alternations ... | |||
TMPY-05342 | IL-17A Protein, Cynomolgus, Recombinant | Cynomolgus | Baculovirus-Insect Cells |
IL17, also known as IL17a, is a cytokine that belongs to the IL-17 family. Cytokines are proteinaceous signaling compounds that are major mediators of the immune response. They control many different cellular functions i... | |||
TMPY-04888 | IL-17 Protein, Rabbit, Recombinant | Rabbit | E. coli |
IL17, also known as IL17a, is a cytokine that belongs to the IL-17 family. Cytokines are proteinaceous signaling compounds that are major mediators of the immune response. They control many different cellular functions i... | |||
TMPY-04710 | IL-17 Protein, Rhesus, Recombinant | Rhesus | Baculovirus-Insect Cells |
IL17, also known as IL17a, is a cytokine that belongs to the IL-17 family. Cytokines are proteinaceous signaling compounds that are major mediators of the immune response. They control many different cellular functions i... | |||
TMPY-03568 | IL-17A Protein, Human, Recombinant (His) | Human | Yeast |
IL17, also known as IL17a, is a cytokine that belongs to the IL-17 family. Cytokines are proteinaceous signaling compounds that are major mediators of the immune response. They control many different cellular functions i... | |||
TMPY-05183 | IL-17A Protein, Human, Recombinant, Biotinylated | Human | E. coli |
IL17, also known as IL17a, is a cytokine that belongs to the IL-17 family. Cytokines are proteinaceous signaling compounds that are major mediators of the immune response. They control many different cellular functions i... | |||
TMPY-04332 | IL-17A Protein, Human, Recombinant (T26A, His) | Human | Baculovirus-Insect Cells |
IL17, also known as IL17a, is a cytokine that belongs to the IL-17 family. Cytokines are proteinaceous signaling compounds that are major mediators of the immune response. They control many different cellular functions i... | |||
TMPY-04609 | IL-17 Protein, Rabbit, Recombinant (His) | Rabbit | Baculovirus-Insect Cells |
IL17, also known as IL17a, is a cytokine that belongs to the IL-17 family. Cytokines are proteinaceous signaling compounds that are major mediators of the immune response. They control many different cellular functions i... | |||
TMPY-03906 | IL-17 Protein, Canine, Recombinant | Canine | E. coli |
IL17, also known as IL17a, is a cytokine that belongs to the IL-17 family. Cytokines are proteinaceous signaling compounds that are major mediators of the immune response. They control many different cellular functions i... | |||
TMPY-03931 | IL-17 Protein, Marmoset, Recombinant | Marmoset | E. coli |
IL17, also known as IL17a, is a cytokine that belongs to the IL-17 family. Cytokines are proteinaceous signaling compounds that are major mediators of the immune response. They control many different cellular functions i... |
カタログ番号 | 製品名 | ||
---|---|---|---|
L4710 | Nonsteroidal Anti-Inflammatory Compound Library | 530 compounds | |
530 non-steroidal anti-inflammatory compounds for high-throughput and high-content screening. |