Powder: -20°C for 3 years | In solvent: -80°C for 1 year
GLN-1062 is a pro-drug of galantamine and liberates galantamine on cleavage by a carboxyesterase in the brain.
説明 | GLN-1062 is a pro-drug of galantamine and liberates galantamine on cleavage by a carboxyesterase in the brain. |
In vivo | GLN-1062 has more than 15-fold higher bioavailability in the brain than the same doses of galantamine. In animal models of drug-induced amnesia, GLN-1062 produced several fold larger cognitive improvement than the same doses of galantamine, without exhibiting any significant levels of gastrointestinal side effects that are typical for the unmodified drug and other inhibitors of cholinesterases, such as donepezil and rivastigmin. In the ferret, dramatically reduced emetic and behavioral responses were observed when GLN-1062 was administered instead of galantamine[1]. |
分子量 | 391.46 |
分子式 | C24H25NO4 |
CAS No. | 224169-27-1 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 45 mg/mL (114.95 mM)
You can also refer to dose conversion for different animals. 詳細
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GLN-1062 224169-27-1 Others GLN 1062 Inhibitor inhibit GLN1062 inhibitor