Powder: -20°C for 3 years | In solvent: -80°C for 1 year
GLP-26, an HBV capsid assembly regulator (CAM), inhibits HBV DNA replication (IC50=3 nM) in the Hep AD38 system and reduces cccDNA by >90% at 1 μM. GLP-26 disrupts the encapsidation of pregenomic RNA, leading to nucleocapsid disassembly and reducing the cccDNA library.
説明 | GLP-26, an HBV capsid assembly regulator (CAM), inhibits HBV DNA replication (IC50=3 nM) in the Hep AD38 system and reduces cccDNA by >90% at 1 μM. GLP-26 disrupts the encapsidation of pregenomic RNA, leading to nucleocapsid disassembly and reducing the cccDNA library. |
ターゲット&IC50 | HBV:0.7 μM(EC50), HBV:3 nM |
In vitro | Administration of 0.7-1.7 μM GLP-26 for 3 days reduces secreted HBeAg in HepNTCP-DL cells transfected with HBV wild type with EC50 values of 0.7 μM[1]. |
分子量 | 373.35 |
分子式 | C19H17F2N3O3 |
CAS No. | 2133017-36-2 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 100 mg/mL (267.85 mM), Sonication is recommended.
You can also refer to dose conversion for different animals. 詳細
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GLP-26 2133017-36-2 Microbiology/Virology HBV GLP26 inhibit GLP 26 Inhibitor Hepatitis B virus inhibitor