store at low temperature,keep away from direct sunlight
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Grasshopper ketone, isolated from the brown alga Sargassum, is a potent inhibitor of LPS-induced NO production in RAW 264.7 cells and induces anti-inflammatory effects by inhibiting MAPK (ERK, JNK and p38) and NF-κB p65 phosphorylation.
説明 | Grasshopper ketone, isolated from the brown alga Sargassum, is a potent inhibitor of LPS-induced NO production in RAW 264.7 cells and induces anti-inflammatory effects by inhibiting MAPK (ERK, JNK and p38) and NF-κB p65 phosphorylation. |
In vitro |
Grasshopper ketone (100 μg/ml) is not cytotoxic to RAW 264.7, and is an effective inhibitor of LPS-induced NO production in RAW 264.7 cells.[1] Grasshopper ketone (0.1-100 μg/ml) significantly reduced pro-inflammatory cytokines, including IL-6, IL-1β, and TNF-α (p<0.05). We confirmed the dose-dependent and significant inhibition of iNOS and COX-2 protein expression.[1] Grasshopper ketone (0.1, 1, 10, 50, and 100 μg/ml,) was found to significantly decrease IFN-γ and IL-4 production in concanavalin A-stimulated splenocytes from BALB/c mice with no cytotoxicity.[3] |
分子量 | 224.3 |
分子式 | C13H20O3 |
CAS No. | 41703-38-2 |
store at low temperature,keep away from direct sunlight
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
You can also refer to dose conversion for different animals. 詳細
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Grasshopper ketone 41703-38-2 Immunology/Inflammation MAPK p38 MAPK ERK JNK NO Synthase Inhibitor inhibitor inhibit