Powder: -20°C for 3 years | In solvent: -80°C for 1 year
NVP-231 is a potent, specific and reversible CerK inhibitor(IC50=12±2 nM) that competitively inhibits ceramide binding to CerK.
パッケージサイズ | 在庫状況 | 単価(税別) |
---|---|---|
5 mg | お問い合わせ | ¥ 7,000 |
10 mg | お問い合わせ | ¥ 11,000 |
25 mg | お問い合わせ | ¥ 18,000 |
50 mg | お問い合わせ | ¥ 29,000 |
100 mg | お問い合わせ | ¥ 47,500 |
1 mL * 10 mM (in DMSO) | お問い合わせ | ¥ 12,500 |
説明 | NVP-231 is a potent, specific and reversible CerK inhibitor(IC50=12±2 nM) that competitively inhibits ceramide binding to CerK. |
ターゲット&IC50 | CreK:12±2 nM |
キナーゼ試験 | For deubiquitinase inhibition assays, 19S regulatory particle (5 nM), 26S (5 nM) UCH-L1 (5 nM), UCH-L3 (0.3 nM), USP2CD (5 nM) USP7CD (5 nM) USP8CD (5 nM) or BAP1 (5 nM) is incubated with DMSO or b-AP15 and monitored the cleavage of ubiquitin-AMC (1,000 nM) using a Wallac VICTOR Multilabel counter or a Tecan Infinite M1000 equipped with 380 nm excitation and 460 nm emission filters[1]. |
分子量 | 431.55 |
分子式 | C25H25N3O2S |
CAS No. | 362003-83-6 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 55 mg/mL (127.45 mM)
You can also refer to dose conversion for different animals. 詳細
bottom
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.
NVP 231 362003-83-6 Apoptosis MAPK ERK inhibit mcf-7 cancer NVP231 cerk Inhibitor NCI-H358 NVP-231 inhibitor