Powder: -20°C for 3 years | In solvent: -80°C for 1 year
H3R-IN-1 Hydrochloride is an inverse agonist of histamine receptor 3( H3R ) .
パッケージサイズ | 在庫状況 | 単価(税別) |
---|---|---|
25 mg | 約10-14 週間 | ¥ 255,000 |
50 mg | 約10-14 週間 | ¥ 333,000 |
100 mg | 約10-14 週間 | ¥ 523,500 |
説明 | H3R-IN-1 Hydrochloride is an inverse agonist of histamine receptor 3( H3R ) . |
In vitro | Treatment with H3R-IN-1, which is a H3R inverse agonist, promotes oligodendrocyte precursor cell (OPC) differentiation in a dose-dependent manner, at EC 50 =25 nM. Western blot shows a significant increase in expression levels of two markers of mature oligodendrocytes, myelin-associated glycoprotein (MAG) and myeline basic protein (MBP) in differentiating oligodendrocytes after treatment with H3R-IN-1, which reveals that treatment with H3R-IN-1 drives more OPCs to differentiate. H3R-IN-1 increases the Forskolin-stimulated cAMP level in the primary oligodendrocyte precursor cells in a dose-dependent manner [1]. |
In vivo | The ability of H3R-IN-1 to enhance remyelination in vivo is determined using the Cuprizone/Rapamycin-induced demyelination model. Mice are treated with Cuprizone diet combined with intraperitoneal injections of Rapamycin for 5 weeks followed by 9 days of compound administration. Cuprizone diet plus intraperitoneal injections of Rapamycin induced severe demyelination in both corpus callosum and cortex and treatment with H3R-IN-1 (30 mg/kg, 9 days) significantly increases density of myelin specific Black-gold II staining in the lesion of corpus callosum and cortex in forebrain, compared to vehicle control group [1]. |
分子量 | 377.87 |
分子式 | C19H24ClN3O3 |
CAS No. | 2319790-07-1 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 25 mg/mL (66.16 mM), Sonication is recommended.
You can also refer to dose conversion for different animals. 詳細
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H3R-IN-1 Hydrochloride 2319790-07-1 GPCR/G Protein Immunology/Inflammation Neuroscience Histamine Receptor H3RIN1 Hydrochloride H3R IN 1 Hydrochloride H-3R-IN-1 Hydrochloride Inhibitor inhibitor inhibit