Powder: -20°C for 3 years | In solvent: -80°C for 1 year
JNJ 10191584 maleate (VUF6002 maleate) is an orally active and selective antagonist of H4 receptor (Ki = 26 nM). JNJ 10191584 maleate inhibits chemotaxis of eosinophils and mast cells (IC50 = 530 nM and 138 nM).
パッケージサイズ | 在庫状況 | 単価(税別) | |||
---|---|---|---|---|---|
サンプルについてお問い合わせ | |||||
1 mg | 在庫あり | ¥ 19,500 | |||
2 mg | 在庫あり | ¥ 29,000 | |||
5 mg | 在庫あり | ¥ 42,000 | |||
10 mg | 在庫あり | ¥ 52,000 | |||
25 mg | 在庫あり | ¥ 114,000 | |||
50 mg | 在庫あり | ¥ 166,000 | |||
100 mg | 在庫あり | ¥ 226,500 |
説明 | JNJ 10191584 maleate (VUF6002 maleate) is an orally active and selective antagonist of H4 receptor (Ki = 26 nM). JNJ 10191584 maleate inhibits chemotaxis of eosinophils and mast cells (IC50 = 530 nM and 138 nM). |
In vitro | JNJ 10191584 maleate shows 540-fold selectivity to H4 receptor(Ki = 14.1 μM)[2]. |
In vivo | In spared nerve injury mice, JNJ 10191584 maleate (10 μg/μL; intra locus coeruleus administration) abolishes VUF-induced anti-allodynic effect and prevents the anti-allodynic effect of VUF 8430. JNJ 10191584 maleate (6 μg/mouse; intrathecal administration) prevents VUF 8430-induced anti-allodynic effect[2]. |
別名 | JNJ 10191584 maleate salt, VUF6002 maleate |
分子量 | 394.81 |
分子式 | C17H19ClN4O5 |
CAS No. | 869497-75-6 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 18mg/mL (45.6mM)
You can also refer to dose conversion for different animals. 詳細
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JNJ 10191584 maleate 869497-75-6 GPCR/G Protein Immunology/Inflammation Neuroscience Histamine Receptor VUF6002 Maleate JNJ 10191584 Maleate JNJ 10191584 maleate salt VUF-6002 Maleate JNJ-10191584 Maleate VUF6002 maleate VUF 6002 Maleate JNJ10191584 Maleate Inhibitor inhibitor inhibit