Powder: -20°C for 3 years | In solvent: -80°C for 1 year
ICCB280 was capable of inducing differentiation and apoptosis of ATRA-resistant patient blasts strongly signify that the activity of this compound can overcome resistance to other current therapies for AML with an unfavorable prognosis.
説明 | ICCB280 was capable of inducing differentiation and apoptosis of ATRA-resistant patient blasts strongly signify that the activity of this compound can overcome resistance to other current therapies for AML with an unfavorable prognosis. |
ターゲット&IC50 | Others:8.6 μM |
In vitro | ICCB280 (10 μM; 2-8 d) increases the C/EBPα expression (mRNA and protein) and modulates its target genes in HL-60 cells.ICCB280 (0.1-50 μM; 48 h) suppresses the HL-60 cell growth, with an IC50 of 8.6 μM[1]. |
分子量 | 386.4 |
分子式 | C23H18N2O4 |
CAS No. | 2041072-41-5 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 55 mg/mL (142.34 mM)
You can also refer to dose conversion for different animals. 詳細
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ICCB280 2041072-41-5 Apoptosis Others Inhibitor ICCB-280 ICCB 280 differentiation proliferation C/EBPα anti-leukemic inhibit inhibitor