Powder: -20°C for 3 years | In solvent: -80°C for 1 year
KCC-07 is a selective, potent and brain-penetrant inhibitor of methyl-CpG-binding domain protein 2(MBD2) with anticancer activity. KCC-07 prevents binding of MBD2 to methylated DNA and activates brain specific angiogenesis inhibitor 1 (BAI1) inducing anti-proliferative BAI1/p53/p21 signaling.
説明 | KCC-07 is a selective, potent and brain-penetrant inhibitor of methyl-CpG-binding domain protein 2(MBD2) with anticancer activity. KCC-07 prevents binding of MBD2 to methylated DNA and activates brain specific angiogenesis inhibitor 1 (BAI1) inducing anti-proliferative BAI1/p53/p21 signaling. |
In vitro | In vitro, KCC-07 treatment Medulloblastomas (MB) cells?clearly inhibited MB cell growth, consistent with induction of anti-proliferative BAI1/p53/p21 signaling |
細胞研究 | KCC-07?treatment?Medulloblastomas (MB) cells, Concentration with?10 μM and?Incubation Time with?72 hours |
分子量 | 269.32 |
分子式 | C14H11N3OS |
CAS No. | 315702-75-1 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 22.5 mg/mL (83.54 mM)
You can also refer to dose conversion for different animals. 詳細
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KCC-07 315702-75-1 DNA Damage/DNA Repair DNA Alkylator/Crosslinker KCC07 BAI1 p53 inhibit ADGRB1 anticancer Inhibitor MBD2 anti-proliferative ADGR KCC 07 brain-penetrant inhibitor