Powder: -20°C for 3 years | In solvent: -80°C for 1 year
LMPTP INHIBITOR 1 hydrochloride is a selective inhibitor of low molecular weight protein tyrosine phosphatase ( LMPTP ), with an IC 50 of 0.8 μM for LMPTP-A.
パッケージサイズ | 在庫状況 | 単価(税別) |
---|---|---|
1 mg | 在庫あり | ¥ 59,500 |
5 mg | 在庫あり | ¥ 147,500 |
10 mg | 在庫あり | ¥ 209,500 |
25 mg | 在庫あり | ¥ 314,500 |
50 mg | 約6-8 週間 | ¥ 424,500 |
1 mL * 10 mM (in DMSO) | 在庫あり | ¥ 168,500 |
説明 | LMPTP INHIBITOR 1 hydrochloride is a selective inhibitor of low molecular weight protein tyrosine phosphatase ( LMPTP ), with an IC 50 of 0.8 μM for LMPTP-A. |
ターゲット&IC50 | LMPTPA:0.8 μM |
In vitro | LMPTP INHIBITOR 1 (hydrochloride) is a selective inhibitor of low molecular weight protein tyrosine phosphatase, with an IC 50 of 0.8 μM for LMPTP-A. LMPTP INHIBITOR 1 shows more potent effect on LMPTP-A versus LMPTP-B. LMPTP inhibitor 1 (Compound 23; 10 μM) also enhances HepG2 IR phosphorylation after insulin stimulation in human HepG2 hepatocytes [1]. |
In vivo | LMPTP inhibitor 1, an orally bioavailable compound, achieves approximately 680 nM mean serum concentration at 0.03% w/w dosage and surpasses 3 μM at 0.05% w/w dosage, effectively reversing diabetes in obese mice. At 0.05% w/w, it inhibits LMPTP activity, markedly enhances glucose tolerance, and lowers fasting insulin levels in diabetic DIO mice without impacting body weight [1]. |
別名 | LMPTP INHIBITOR 1 hydrochloride (1908414-82-3(free base)) |
分子量 | 481.07 |
分子式 | C28H37ClN4O |
CAS No. | 2310135-38-5 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 9 mg/mL (18.71 mM)
You can also refer to dose conversion for different animals. 詳細
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LMPTP INHIBITOR 1 hydrochloride 2310135-38-5 Metabolism Phosphatase LMPTP INHIBITOR 1 Hydrochloride LMPTP INHIBITOR 1 hydrochloride (1908414-82-3(free base)) Inhibitor inhibitor inhibit