store at low temperature
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Lanabecestat (AZD3293) is a highly potent and highly permeable, orally active BACE1 inhibitor (Ki: 0.4 nM) that crosses the blood-brain barrier.Lanabecestat can be used for the study of neurological diseases such as Alzheimer's disease.
パッケージサイズ | 在庫状況 | 単価(税別) |
---|---|---|
2 mg | 在庫あり | ¥ 26,000 |
25 mg | 約8-10 週間 | ¥ 158,000 |
50 mg | 約8-10 週間 | ¥ 209,500 |
100 mg | 約8-10 週間 | ¥ 333,000 |
説明 | Lanabecestat (AZD3293) is a highly potent and highly permeable, orally active BACE1 inhibitor (Ki: 0.4 nM) that crosses the blood-brain barrier.Lanabecestat can be used for the study of neurological diseases such as Alzheimer's disease. |
ターゲット&IC50 | BACE1:0.4 nM (cell free), BACE1:0.4 nM |
In vitro | Lanabecestat differentially altered the protein levels of microglia in 5xFAD and APP KI mice[1]. |
In vivo | Lanabecestat treatment (1 mg/kg; oral gavage; once daily; for 3 weeks) increased the bursting frequency in 4-AP-induced cell models in Bace1-null mice[1]. |
別名 | LY3314814, AZD3293 |
分子量 | 412.53 |
分子式 | C26H28N4O |
CAS No. | 1383982-64-6 |
store at low temperature
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 80 mg/mL (193.92 mM), Sonication is recommended.
You can also refer to dose conversion for different animals. 詳細
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.
Lanabecestat 1383982-64-6 Neuroscience BACE AZD-3293 LY3314814 AZD 3293 LY-3314814 AZD3293 LY 3314814 Inhibitor inhibitor inhibit