Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Lometrexol (LY 264618), an antipurine Antifolate, can inhibit the activity of glycinamide ribonucleotide formyltransferase (GARFT) but do not induce detectable levels of DNA strand breaks. Lometrexol can further inhibit de novo purine synthesis, causing abnormal cell proliferation and Apoptosis, even cell cycle arrest. Lometrexol has anticancer activity. Lometrexol also is a potent human Serine hydroxymethyltransferase1/2 (hSHMT1/2) inhibitor.
パッケージサイズ | 在庫状況 | 単価(税別) | |||
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サンプルについてお問い合わせ | |||||
1 mg | 在庫あり | ¥ 22,500 | |||
5 mg | 在庫あり | ¥ 54,000 | |||
10 mg | 在庫あり | ¥ 79,000 | |||
25 mg | 在庫あり | ¥ 133,000 | |||
50 mg | 在庫あり | ¥ 190,500 | |||
100 mg | 在庫あり | ¥ 264,000 | |||
1 mL * 10 mM (in DMSO) | 在庫あり | ¥ 63,000 |
説明 | Lometrexol (LY 264618), an antipurine Antifolate, can inhibit the activity of glycinamide ribonucleotide formyltransferase (GARFT) but do not induce detectable levels of DNA strand breaks. Lometrexol can further inhibit de novo purine synthesis, causing abnormal cell proliferation and Apoptosis, even cell cycle arrest. Lometrexol has anticancer activity. Lometrexol also is a potent human Serine hydroxymethyltransferase1/2 (hSHMT1/2) inhibitor. |
In vitro | Lometrexol binds tightly to GART, resulting in a rapid and prolonged depletion of intracellular purine ribonucleotides. Lometrexol (1-30 μM; 2-10 hours) induces rapid and complete growth inhibition in L1210 cells. Lometrexol (1 μM; 2-24 hours) induces cell cycle arrest in murine leukemia L1210 cells[3]. |
In vivo | Lometrexol (DDATHF; i.p.; 15-60 mg/kg; on gestation day 7.5) induces neural tube defects (NTDs) by disturbing purine metabolism and increases the rate of embryonic resorption and growth retardation in a dose-dependent manner. Lometrexol (i.p.; 40 mg/kg; on gestation day 7.5) decreases glycinamide ribonucleotide formyl transferase (GARFT) activity and Changes of ATP, GTP, dATP and dGTP levels[1]. Lometrexol (i.p.; 40 mg/kg; on gestation day 7.5) induces abnormal proliferation and apoptosis exist in neural tube defects (NTDs)[1]. |
別名 | LY 264618, DDATHF |
分子量 | 443.45 |
分子式 | C21H25N5O6 |
CAS No. | 106400-81-1 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 36mg/mL (81.2mM)
You can also refer to dose conversion for different animals. 詳細
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Lometrexol 106400-81-1 Cell Cycle/Checkpoint DNA Damage/DNA Repair Metabolism DHFR LY 264618 LY264618 LY-264618 DDATHF Inhibitor inhibitor inhibit