Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Loxoribine (RWJ 21757) is a guanosine analog. Loxoribine is an orally bioavailable and selective Toll-like receptor (TLR) 7 agonist. It has anti-viral and anti-tumor activities.Loxoribine is a potent new immunostimulant with a relatively broad spectrum of immunobiological activities.
パッケージサイズ | 在庫状況 | 単価(税別) | |||
---|---|---|---|---|---|
サンプルについてお問い合わせ | |||||
5 mg | 在庫あり | ¥ 10,000 | |||
10 mg | 在庫あり | ¥ 16,000 | |||
25 mg | 在庫あり | ¥ 27,000 | |||
50 mg | 在庫あり | ¥ 39,500 | |||
100 mg | 在庫あり | ¥ 58,500 | |||
1 mL * 10 mM (in DMSO) | 在庫あり | ¥ 11,000 |
説明 | Loxoribine (RWJ 21757) is a guanosine analog. Loxoribine is an orally bioavailable and selective Toll-like receptor (TLR) 7 agonist. It has anti-viral and anti-tumor activities.Loxoribine is a potent new immunostimulant with a relatively broad spectrum of immunobiological activities. |
In vitro | Loxoribine selectively activates innate immune system cells through the Toll-like receptor (TLR) 7/MyD88-dependent signaling pathway[1], leading to the maturation of human monocyte-derived dendritic cells (DCs) and enhancing their Th-1- and Th-17-polarizing capability[2]. Additionally, loxoribine (250 μM; 48 hours) promotes MoDCs maturation, evident from the increased expression of CD80, CD83, CD40, CD54, and CCR7[2]. |
In vivo | In vivo, Loxoribine (2 mg; s.c.or i.v.) activates murine natural killer (NK) cells[3]. |
別名 | RWJ 21757, 7-Allyl-8-oxoguanosine |
分子量 | 339.3 |
分子式 | C13H17N5O6 |
CAS No. | 121288-39-9 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 27.5 mg/mL (81.05 mM)
You can also refer to dose conversion for different animals. 詳細
bottom
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.
Loxoribine 121288-39-9 Immunology/Inflammation Microbiology/Virology TLR Influenza Virus RWJ 21757 natural Toll-like Receptor (TLR) killer,cells Inhibitor RWJ-21757 RWJ21757 cells 7-Allyl-8-oxoguanosine inhibit TLR-7 MoDCs inhibitor