Powder: -20°C for 3 years | In solvent: -80°C for 1 year
ML382 is a potent and selective MrgX1 positive allosteric modulator(EC50 : 190 nM).
パッケージサイズ | 在庫状況 | 単価(税別) | |||
---|---|---|---|---|---|
サンプルについてお問い合わせ | |||||
1 mg | 在庫あり | ¥ 7,000 | |||
5 mg | 在庫あり | ¥ 16,000 | |||
10 mg | 在庫あり | ¥ 26,000 | |||
25 mg | 在庫あり | ¥ 50,500 | |||
50 mg | 在庫あり | ¥ 91,500 | |||
100 mg | 在庫あり | ¥ 135,500 | |||
1 mL * 10 mM (in DMSO) | 在庫あり | ¥ 17,500 |
説明 | ML382 is a potent and selective MrgX1 positive allosteric modulator(EC50 : 190 nM). |
ターゲット&IC50 | MrgX1:190 nM(EC50) |
In vivo | ML382 enhances the ability of BAM8-22 to inhibit high-voltage-activated Ca2+ channels and attenuate spinal nociceptive transmission, both BAM8-22 and ML382 effectively attenuated evoked, persistent, and spontaneous pain without causing obvious side effects.?Notably, ML382 by itself attenuated both evoked pain hypersensitivity and spontaneous pain in MrgprX1 mice after nerve injury without acquiring coadministration of an exogenous agonist[2] |
分子量 | 360.43 |
分子式 | C18H20N2O4S |
CAS No. | 1646499-97-9 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 32.5 mg/mL (90.17 mM)
You can also refer to dose conversion for different animals. 詳細
bottom
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.
ML382 1646499-97-9 Others Inhibitor nociceptor pain injury DRG inhibit neurons nervous ML 382 ML-382 inhibitor