Powder: -20°C for 3 years | In solvent: -80°C for 1 year
MMAF sodium is widely used as a cytotoxic component of antibody-drug conjugates (ADCs) such as Vorsetuzumab mafodotin and SGN-CD19A. MMAF sodium is an effective tubulin polymerization inhibitor and is used as an antitumor agent.
説明 | MMAF sodium is widely used as a cytotoxic component of antibody-drug conjugates (ADCs) such as Vorsetuzumab mafodotin and SGN-CD19A. MMAF sodium is an effective tubulin polymerization inhibitor and is used as an antitumor agent. |
In vitro | MMAF suppresses anaplastic large cell lymphoma Karpas 299, breast carcinoma H3396, renal cell carcinoma 786-O, and Caki-1 cells. It has IC50s of 119, 105, 257, and 200 nM in vitro cytotoxicity assay[4]. |
別名 | Monomethylauristatin F sodium |
分子量 | 754.966 |
分子式 | C39H65N5NaO8 |
CAS No. | 1799706-65-2 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 200 mg/mL (265.27 mM)
You can also refer to dose conversion for different animals. 詳細
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MMAF sodium 1799706-65-2 Membrane transporter/Ion channel ABC Monomethylauristatin F sodium Inhibitor inhibitor inhibit