Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Minalrestat(ARI-509) is an orally active and potent aldose reductase inhibitor for the study of impaired microvascular reactivity in diabetic patients.
パッケージサイズ | 在庫状況 | 単価(税別) |
---|---|---|
1 mg | 在庫あり | ¥ 59,500 |
5 mg | 在庫あり | ¥ 147,500 |
10 mg | 在庫あり | ¥ 209,500 |
25 mg | 在庫あり | ¥ 314,500 |
50 mg | 在庫あり | ¥ 424,500 |
説明 | Minalrestat(ARI-509) is an orally active and potent aldose reductase inhibitor for the study of impaired microvascular reactivity in diabetic patients. |
In vitro |
Minalrestat (100 μM) reduces intracellular sorbitol content in primary cultured rat cells without affecting intracellular glucose levels.[3] Minalrestat (100 μM, 48 h) causes the accumulation of PKC-α and -β2 in primary cultured rat mesangial cells.[3] |
In vivo | The diabetic group was treated from 3 days after the alloxan injection with Minalrestat (10 mg/kg/day) for 30 days and the Minalrestat treatment (10 mg/kg/day/7 days) of galactosemic rats started concomitantly with the induction of galactosemia. The impaired responses to bradykinin, histamine, and platelet-activating factors of arterioles and venules observed in diabetic and galactosemic rats were completely prevented by Minalrestat. Neither diabetes nor galactosemia affected responses to acetylcholine and sodium nitroprusside. Responses to these agents were not modified by aldose reductase inhibition. The restoring effect of Minalrestat was reversed by inhibition of nitric oxide (NO) synthesis with N(omega)-nitro-L-arginine methyl ester, by blocking K(+) channel with tetraethylammonium but not by cyclooxygenase inhibition with diclofenac.[1] |
別名 | ARI509, WAY-121509, WAY121509, WAYARI-509, ARI-509, WAY-ARI-509 |
分子量 | 449.2 |
分子式 | C19H11BrF2N2O4 |
CAS No. | 129688-50-2 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
You can also refer to dose conversion for different animals. 詳細
bottom
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.
Minalrestat 129688-50-2 Endocrinology/Hormones Metabolism Reductase ARI509 WAY-121509 ARI 509 WAY-ARI509 WAY-ARI 509 WAY121509 WAYARI 509 WAYARI-509 WAY 121509 ARI-509 WAYARI509 WAY-ARI-509 Inhibitor inhibitor inhibit