Powder: -20°C for 3 years | In solvent: -80°C for 1 year
NNC 05-2090 hydrochloride is a betaine/GABA transporter (BGT-1) inhibitor with an IC50 value of 10.6 μM.NNC 05-2090 hydrochloride can be used for the study of epilepsy and neurological disorders.
パッケージサイズ | 在庫状況 | 単価(税別) | |||
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1 mg | 在庫あり | ¥ 10,000 | |||
5 mg | 在庫あり | ¥ 24,000 | |||
10 mg | 在庫あり | ¥ 39,500 | |||
25 mg | 在庫あり | ¥ 89,500 | |||
50 mg | 在庫あり | ¥ 160,000 | |||
100 mg | 在庫あり | ¥ 248,000 |
説明 | NNC 05-2090 hydrochloride is a betaine/GABA transporter (BGT-1) inhibitor with an IC50 value of 10.6 μM.NNC 05-2090 hydrochloride can be used for the study of epilepsy and neurological disorders. |
In vitro |
NNC05-2090 hydrochloride binds to prazosin and spiperone with IC50 values of 266 nM and 1632 nM, respectively.[1] NNC05-2090 hydrochloride (0.1-100 μM) inhibits [3H]GABA uptake in rat cortical synaptosomes with an IC50 value of 4.4 μM.[1] NNC05-2090 hydrochloride (0.1-100 μM) inhibits [3H]GABA uptake in inferior colliculus synaptosomes with an IC50 value of 2.5 μM.[1] NNC05-2090 hydrochloride inhibits serotonin, norepinephrine, dopamine transporter, and BGT-1 with IC50 values of 5.29, 7.91, 4.08, and 10.6 μM respectively.[1] NNC05-2090 hydrochloride inhibits GAT-1, GAT-2 and GAT-3 with IC50s of 29.62, 45.29 and 22.51 μM respectively.[1] |
In vivo |
NNC05-2090 hydrochloride (i.p.; PSL mice) dose-dependently protects mice from maximal electric shock (MES) ED50 of 73 μmol/kg and against tonic and clonic convulsions in DBA/2 mice with an ED50 of 19 μmol /kg and 26 μmol/kg.[1] NNC05-2090 hydrochloride (0.01, 0.1, 0.3 mg/kg; intraperitoneal or intrathecal injection; once) can dose-dependently reverse mechanical allodynia in PSL model mice by both intraperitoneal injection and intrathecal injection.[2] |
分子量 | 451 |
分子式 | C27H31ClN2O2 |
CAS No. | 184845-18-9 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Ethanol: < 5.64 mg/mL
DMSO: < 45.1 mg/mL
You can also refer to dose conversion for different animals. 詳細
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NNC 05-2090 hydrochloride 184845-18-9 Metabolism Transaminase NNC 05 2090 hydrochloride NNC 05-2090 Hydrochloride NNC 052090 hydrochloride Inhibitor inhibitor inhibit