Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Nelonemdaz (Neu2000) is an NMDA receptor antagonist with antioxidant activity and neuroprotective activity used in the study of cerebral infarction reperfusion injury and acute ischemic stroke.
説明 | Nelonemdaz (Neu2000) is an NMDA receptor antagonist with antioxidant activity and neuroprotective activity used in the study of cerebral infarction reperfusion injury and acute ischemic stroke. |
In vitro | Nelonemdaz (0.19-12.5 μM) dose-dependently reduces the amount of reactive oxygen species/nitrogen species (ROS/RNS) formation induced by Antimycin A and inhibits the formation of malondialdehyde (MDA)[3]. |
In vivo | In male Sprague-Dawley rats weighing 260 to 300 g (subjected to the clip occlusion model), Nelonemdaz (0.5-20 mg/kg; intravenous administration 5 minutes after reperfusion) exhibited significant neuroprotective effects[1]. |
別名 | Salfaprodil free base, Neu2000 |
分子量 | 383.22 |
分子式 | C15H8F7NO3 |
CAS No. | 640290-67-1 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 100 mg/mL (260.95 mM), Sonication is recommended.
You can also refer to dose conversion for different animals. 詳細
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Nelonemdaz 640290-67-1 Neuroscience oxidation-reduction Antioxidant NMDAR Salfaprodil free base Neu2000 Inhibitor inhibitor inhibit