Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Gimatecan (STI481) is a potent topoisomerase I inhibitor. Gimatecan is an orally bioavailable camptothecin analogue with antitumor activity.
パッケージサイズ | 在庫状況 | 単価(税別) | |||
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1 mg | 在庫あり | ¥ 27,000 | |||
5 mg | 在庫あり | ¥ 66,000 | |||
10 mg | 在庫あり | ¥ 110,000 | |||
25 mg | 在庫あり | ¥ 181,000 | |||
50 mg | 在庫あり | ¥ 248,000 | |||
1 mL * 10 mM (in DMSO) | 在庫あり | ¥ 73,000 |
説明 | Gimatecan (STI481) is a potent topoisomerase I inhibitor. Gimatecan is an orally bioavailable camptothecin analogue with antitumor activity. |
In vitro | Gimatecan (3 to 300 ng/mL) significantly inhibits the growth of human bladder cancer models (HT1376 and MCR), thus reflecting antiproliferative potency. Gimatecan causes a persistent S-phase arrest At 0.003 µg/mL and the number of S-phase cells increased after treatment with a higher concentration (0.03 µg/mL)[1]. |
In vivo | Gimatecan (2 mg/kg; treatment per os, every fourth day for four times) is effective for inhibiting tumor growth[1]. |
別名 | LBQ707, STI481 |
分子量 | 447.48 |
分子式 | C25H25N3O5 |
CAS No. | 292618-32-7 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 31.5 mg/mL (70.4 mM), when pH is adjusted to 10 with NaOH. Sonication and heating to 60℃ are recommended.
H2O: Insoluble
You can also refer to dose conversion for different animals. 詳細
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Gimatecan 292618-32-7 DNA Damage/DNA Repair Topoisomerase LBQ707 STI-481 STI 481 LBQ-707 STI481 LBQ 707 Inhibitor inhibitor inhibit