keep away from moisture
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Neuropeptide W-23(human) (NPW-23) is an endogenous ligand for NPBW1 and NPBW2.
パッケージサイズ | 在庫状況 | 単価(税別) | |||
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1 mg | 在庫あり | ¥ 28,500 | |||
2 mg | 在庫あり | ¥ 45,000 | |||
5 mg | 在庫あり | ¥ 85,500 | |||
10 mg | 在庫あり | ¥ 123,500 | |||
25 mg | 在庫あり | ¥ 196,500 | |||
50 mg | 在庫あり | ¥ 264,000 | |||
100 mg | 在庫あり | ¥ 356,000 | |||
500 mg | 在庫あり | ¥ 682,000 |
説明 | Neuropeptide W-23(human) (NPW-23) is an endogenous ligand for NPBW1 and NPBW2. |
In vitro | NPW-23 increases the ICa,L in transfected human embryonic kidney 293 cells and VSMCs via GPR7 which may involve in the development of vascular hypertension. NPW-23 increases the expression of pan phospho-PKC, intracellular diacylglycerol level, and the second messenger catalyzed by PLC[1]. |
In vivo | NPW-23 increases pressure-induced vasotone of the rat mesenteric arteries. Importantly, the expression of NPW is decreased in the hypertensive rats[1]. NPW-23 (0.3 nmol, 1.0 nmol, and 3.0 nmol) induces significant increases in mean arterial pressure (MAP) in conscious, freely moving male rats. Rats that receive either 1.0 or 3.0 nmol NPW-23 demonstrate a significant increase in total activity, ambulatory activity, and duration of stereotypy. NPW-23 fails to elevate MAP in rats pretreated with phentolamine. NPW-23-induced increases in total activity, ambulatory activity, and duration of stereotypy are reduced significantly by pretreatment with the orexin type 1 receptor (OX1R) antagonist, SB-408124 which suggests that orexin neurons are downstream targets of NPW [2]. |
別名 | NPW-23 |
分子量 | 2584.01 |
分子式 | C119H183N35O28S |
CAS No. | 383415-79-0 |
keep away from moisture
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
H2O: Soluble
You can also refer to dose conversion for different animals. 詳細
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Neuropeptide W-23(human) 383415-79-0 Others Neuropeptide W23(human) Neuropeptide W-23 hypetension anorexigenic effect Neuropeptide W 23(human) Neuropeptide W-23 (human) NPW23 GPR7 Inhibitor Neuropeptide W GPR8 NPBW1 NPW-23 NPBW2 NPW 23 inhibit inhibitor