Powder: -20°C for 3 years | In solvent: -80°C for 1 year
PCNA-I1 is an inhibitor targeting PCNA chromatin association in prostate cancer.
説明 | PCNA-I1 is an inhibitor targeting PCNA chromatin association in prostate cancer. |
In vitro | PCNA-I1 induced DNA damage and apoptosis in both LNCaP and PC-3 cells and enhanced DNA damage and apoptosis triggered by cisplatin.?PCNA-I1 also induced autophagy in PC-3 cells.?A short-term pretreatment with PCNA-I1 reduced colony formation by 50% in both cell lines.[1] |
In vivo | Intravenous administrations of PCNA-I1 significantly retarded growth of LNCaP tumors of in nude mice without causing detectable effects on mouse body weight and hematology profiles[1]. |
分子量 | 310.37 |
分子式 | C17H14N2O2S |
CAS No. | 444930-42-1 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 3.1 mg/mL (10 mM), Sonication is recommended.
You can also refer to dose conversion for different animals. 詳細
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PCNA-I1 444930-42-1 Others PCNA-I-1 DNA/RNA Synthesis inhibit PCNAI1 Inhibitor PCNA I1 inhibitor