Powder: -20°C for 3 years | In solvent: -80°C for 1 year
PCS1055 dihydrochloride is an effective, selective, and competitive muscarinic M4 receptor antagonist (IC50: 18.1 nM and a Kd: 5.72 nM). PCS1055 dihydrochloride is also a potent AChE inhibitor (IC50 s: 22 nM and 120 nM for electric eel and human AChE, res
パッケージサイズ | 在庫状況 | 単価(税別) |
---|---|---|
25 mg | 約6-8 週間 | ¥ 349,000 |
50 mg | 約6-8 週間 | ¥ 454,500 |
100 mg | 約6-8 週間 | ¥ 574,000 |
ターゲット&IC50 | M4 mAChR:(kd)5.72 nM, M4 mAChR:18.1 nM |
In vitro | PCS1055 effectively inhibits G protein activation in a concentration-dependent manner, demonstrating its highest potency at M4 receptors. Research indicates that PCS1055 shows a pronounced binding and functional preference for the M4 receptor subtype, surpassing its affinity and effectiveness for M1-, M2-, M3-, and M5 receptors by 130-, 31.2-, 426-, and >1000-fold, and 255-, 69.1-, 342-, and >1000-fold, respectively. Furthermore, PCS1055 counteracts functional signal transduction, evidenced by its ability to inhibit agonist-stimulated GTP-γ-[35S] binding, showcasing its antagonistic properties. |
分子量 | 485.49 |
分子式 | C27H34Cl2N4 |
CAS No. | 361979-40-0 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
You can also refer to dose conversion for different animals. 詳細
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PCS1055 dihydrochloride 361979-40-0 Others PCS1055 PCS 1055 PCS-1055 Dihydrochloride PCS-1055 PCS 1055 Dihydrochloride PCS-1055 dihydrochloride PCS1055 Dihydrochloride Inhibitor inhibitor inhibit