Powder: -20°C for 3 years | In solvent: -80°C for 1 year
PD 90780 is a non peptide antagonist of nerve growth factor (NGF). PD 90780 interacts with NGF, prevents NGF binds with p75NTR. PD 90780 inhibits NGF-p75NTR interaction with IC50s of 23.1 and 1.8 µM in PC12 cells and PC12nnr5 cells, respectively.
パッケージサイズ | 在庫状況 | 単価(税別) | |||
---|---|---|---|---|---|
サンプルについてお問い合わせ | |||||
1 mg | 在庫あり | ¥ 12,000 | |||
5 mg | 在庫あり | ¥ 28,000 | |||
10 mg | 在庫あり | ¥ 45,500 | |||
25 mg | 在庫あり | ¥ 91,500 | |||
50 mg | 在庫あり | ¥ 135,500 | |||
100 mg | 在庫あり | ¥ 193,500 | |||
1 mL * 10 mM (in DMSO) | 在庫あり | ¥ 30,500 |
説明 | PD 90780 is a non peptide antagonist of nerve growth factor (NGF). PD 90780 interacts with NGF, prevents NGF binds with p75NTR. PD 90780 inhibits NGF-p75NTR interaction with IC50s of 23.1 and 1.8 µM in PC12 cells and PC12nnr5 cells, respectively. |
ターゲット&IC50 | NGF (PC12 nnr5 cells):1.8 µM , NGF (PC12 cells):23.1 µM |
In vitro | PD 90780 (0.1-100 μM; 2 h) affects 125I-BDNF binds to truncated p75NTR. PD 90780 (100 μM; 2 h) inhibits 125I-NGF cross-linking to p75NTR. PD 90780 (0-300 μM; 2 h) decreases TrkA phosphorylation resulting from NGF binding with a dose of 300 μM. PD 90780 (0.1-100 μM; 2 h) inhibits NGF-p75NTR interaction with IC50 values of 23.1 µM and 1.8 µM in PC12 cells and PC12nnr5 cells, respectively[1]. |
分子量 | 362.34 |
分子式 | C19H14N4O4 |
CAS No. | 77422-99-2 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 28.8 mg/mL (79.5 mM), Sonication and heating to 60℃ are recommended.
You can also refer to dose conversion for different animals. 詳細
bottom
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.
PD 90780 77422-99-2 Others PD-90780 PD90780 Inhibitor inhibitor inhibit