Powder: -20°C for 3 years | In solvent: -80°C for 1 year
PNU-142633 has anti-migraine efficacy. PNU-142633 is a high affinity and selective 5-HT1D receptor agonist (Kis of 6 nM and > 18 000 nM for human 5-HT1D receptor and human 5-HT1B receptor, respectively).
説明 | PNU-142633 has anti-migraine efficacy. PNU-142633 is a high affinity and selective 5-HT1D receptor agonist (Kis of 6 nM and > 18 000 nM for human 5-HT1D receptor and human 5-HT1B receptor, respectively). |
ターゲット&IC50 | 5-HT1D receptor:6 nM (ki) |
In vitro | Compared with 84% for that of Sumatriptan, in a cytosensor cell-based assay, the intrinsic activity of PNU-142633 at the human 5-HT1D receptor is determined to be 70% that of 5-HT [1]. |
In vivo | PNU-142633 fails to alter resistance in these vascular beds. PNU-142633 (0.03-1 mg/kg; intravenous injection; male Hartley guinea pigs) treatment blocks neurogenic plasma protein extravasation [1]. |
分子量 | 422.52 |
分子式 | C24H30N4O3 |
CAS No. | 187665-65-2 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
You can also refer to dose conversion for different animals. 詳細
bottom
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.
PNU-142633 187665-65-2 GPCR/G Protein Neuroscience 5-HT Receptor PNU142633 PNU 142633 Inhibitor inhibitor inhibit