Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Phellamurin inhibits intestinal P-glycoprotein in a dose-dependent manner, there is a serious interaction occurred between Phellamurin with cyclosporin, to ensure the efficacy of cyclosporin, we suggest that the coadministration of Phellamurin or Phellodendron wilsonii with cyclosporin should be avoided.
パッケージサイズ | 在庫状況 | 単価(税別) | |||
---|---|---|---|---|---|
サンプルについてお問い合わせ | |||||
1 mg | 在庫あり | ¥ 38,000 | |||
5 mg | 在庫あり | ¥ 77,500 | |||
10 mg | 在庫あり | ¥ 114,000 | |||
25 mg | 在庫あり | ¥ 182,000 | |||
50 mg | 在庫あり | ¥ 259,500 | |||
100 mg | 在庫あり | ¥ 349,000 | |||
1 mL * 10 mM (in DMSO) | 在庫あり | ¥ 99,500 |
説明 | Phellamurin inhibits intestinal P-glycoprotein in a dose-dependent manner, there is a serious interaction occurred between Phellamurin with cyclosporin, to ensure the efficacy of cyclosporin, we suggest that the coadministration of Phellamurin or Phellodendron wilsonii with cyclosporin should be avoided. |
In vitro | Administration of 0-10?μg/mL Phellamurin for 48 hours in U2OS and Saos-2?cells leads to a repression of cell viability dose-dependently, promotes the apoptosis of U2OS and Saos-2?cells concentration-dependently, and declines the ratios of p-PI3K/PI3K, p-AKT/AKT, and p-mTOR/mTOR in U2OS and Saos-2?cells[1]. |
In vivo | Intraperitoneal injection of 50?mg/kg/day Phellamurin daily for 21 days in female BALB/c nude mice represses osteosarcoma tumor growth in vivo. The ratios of p-PI3K/PI3K, p-AKT/AKT, and p-mTOR/mTOR are decreased in xenograft in Phellamurin-treated mice[1]. |
植物由来 |
分子量 | 518.51 |
分子式 | C26H30O11 |
CAS No. | 52589-11-4 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 55 mg/ml (106.07 mM)
You can also refer to dose conversion for different animals. 詳細
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Phellamurin 52589-11-4 Membrane transporter/Ion channel Neuroscience P-gp Cluster of differentiation 243 intestinal anti-tumor inhibit MDR1 Pgp CD243 glycoside p-AKT p-mTOR p-PI3K Multidrug resistance protein 1 P-glycoprotein ABCB1 Apoptosis Flavonone Inhibitor inhibitor