keep away from moisture
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Protirelin (Thyroliberin) is a tripeptide that stimulates the release of thyrotropin and prolactin.
パッケージサイズ | 在庫状況 | 単価(税別) |
---|---|---|
5 mg | 約5 days | ¥ 11,000 |
10 mg | 約5 days | ¥ 15,000 |
25 mg | 約5 days | ¥ 31,000 |
50 mg | 約5 days | ¥ 50,000 |
1 mL * 10 mM (in DMSO) | 約5 days | ¥ 11,500 |
説明 | Protirelin (Thyroliberin) is a tripeptide that stimulates the release of thyrotropin and prolactin. |
ターゲット&IC50 | THR: |
In vivo | Protirelin (TRH), a neuropeptide predating the split between protostomes and deuterostomes, has likely played a role in regulating postembryonic growth and reproduction from its evolutionary origins. This study explores Protirelin's impact on body temperature, specifically through the administration of 1, 5, 10, and 20 mg/kg doses intraperitoneally to male Wistar rats (200-250 g). The findings reveal that Protirelin induces a temporary, dose-dependent increase in body temperature. Notably, thyroidectomized rats receiving a 20 mg/kg dose of Protirelin do not exhibit the significant hyperthermia observed in sham-operated counterparts, indicating that thyroid hormone release may be essential to Protirelin's hyperthermic effect. |
動物実験 | Protirelin (TRH tartRatse) is dissolved in physiological saline (Rats).RatsNinety male Wistar rats weighing 200-250 g are subjected to the study. In the first experiment, 50 rats are divided into five groups randomly. Four doses of Protirelin dissolved in physiological saline, i. e., 1 mg/kg, 5 mg/kg, 10 mg/kg and 20 mg/kg, are administered intraperitoneally to the four groups and saline to the remaining control group. Rectal temperature is measured at the place 5 cm inner from the anus with the electronic thermister before and after treatment with Protirelin or saline. In the second experiment, 40 rats are thyroidectomized or sham-operated under the anesthesia by thiopental sodium. Ten days after the operation, 20 mg/kg of Protirelin or saline is administered to the thyroidectomized and sham-operated animals by i. p. and rectal temperature is measured using the same method as used in the first experiment. These two experiments are undertaken from 1 p, m, to 4 p. m. and the room temperature is kept at 24±1°C through the experiments including the breeding period. For a statistical analysis, Student's t test (two-tailed) is adopted. |
別名 | Lopremone, pGlu-His-Pro-NH2, Synthetic thyrotropin-releasing hormone, Thyroliberin, TRH, TRF |
分子量 | 362.38 |
分子式 | C16H22N6O4 |
CAS No. | 24305-27-9 |
keep away from moisture
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Ethanol: 67 mg/mL (184.9 mM)
DMSO: 67 mg/mL (184.9 mM)
H2O: 66 mg/mL (182.1 mM)
You can also refer to dose conversion for different animals. 詳細
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.
Protirelin 24305-27-9 Endocrinology/Hormones Metabolism Endogenous Metabolite Thyroid hormone receptor(THR) THR Lopremone pGlu-His-Pro-NH2 Synthetic thyrotropin-releasing hormone Inhibitor Thyroliberin Thyroid Hormone Receptor TRH inhibit TRF inhibitor