Powder: -20°C for 3 years | In solvent: -80°C for 1 year
RH01386 is a small molecule that can prevent ER stress-induced β cell dysfunction and death, and inhibits proapoptotic gene expression,has the potential for type 2 diabetes treatment. RH01386 restores ER stress-impaired glucose-stimulated insulin secretion responses.
説明 | RH01386 is a small molecule that can prevent ER stress-induced β cell dysfunction and death, and inhibits proapoptotic gene expression,has the potential for type 2 diabetes treatment. RH01386 restores ER stress-impaired glucose-stimulated insulin secretion responses. |
In vitro | ATP levels in βTC6 cells treated with (tunicamycin) Tm increase by RH01386.RH01386 exhibits a EC50 value of 1.894 μM. RH01386 dose-dependently inhibits (tunicamycin) Tm-induced cell death, and inhibits the activity of caspase-3, a downstream effector of the apoptotic pathway in βTC6 cells. |
分子量 | 424.4 |
分子式 | C18H15F3N4O3S |
CAS No. | 301177-36-6 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 55 mg/mL (129.59 mM)
You can also refer to dose conversion for different animals. 詳細
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RH01386 301177-36-6 Others RH 01386 βTC6 cells inhibit Apoptosis RH-01386 Inhibitor type 2 diabetes β cell inhibitor