Powder: -20°C for 3 years | In solvent: -80°C for 1 year
RO 4938581 is an effective and selective agonist of GABAA α5 inverse (Ki: 4.6 nM for GABAA α5β3γ2a, and shows a lower affinity at α1β3γ2a, α2β3γ2a, α3β3γ2a (Ki, 174, 185, 80 nM, respectively)).
パッケージサイズ | 在庫状況 | 単価(税別) |
---|---|---|
25 mg | 約6-8 週間 | ¥ 282,500 |
50 mg | 約6-8 週間 | ¥ 369,500 |
100 mg | 約6-8 週間 | ¥ 608,500 |
説明 | RO 4938581 is an effective and selective agonist of GABAA α5 inverse (Ki: 4.6 nM for GABAA α5β3γ2a, and shows a lower affinity at α1β3γ2a, α2β3γ2a, α3β3γ2a (Ki, 174, 185, 80 nM, respectively)). |
ターゲット&IC50 | GABAA α2β3γ2a:185 nM(ki), GABAA α1β3γ2a:174 nM(ki), GABAA α3β3γ2a:80 nM, GABAA α5β3γ2a:(ki)4.6 nM |
In vivo | RO 4938581 (0.3-1 mg/kg, p.o.) reverses a working memory impairment induced by scopolamine the delayed match to position task [1]. |
分子量 | 352.14 |
分子式 | C13H8BrF2N5 |
CAS No. | 883093-10-5 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
You can also refer to dose conversion for different animals. 詳細
bottom
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.
RO 4938581 883093-10-5 Membrane transporter/Ion channel Neuroscience GABA Receptor RO4938581 RO-4938581 Inhibitor inhibitor inhibit