Powder: -20°C for 3 years | In solvent: -80°C for 1 year
RO-9187 is an effective HCV virus replication inhibitor(IC50: 171 nM).
パッケージサイズ | 在庫状況 | 単価(税別) |
---|---|---|
2 mg | 約 5 days | ¥ 26,000 |
5 mg | 約 5 days | ¥ 54,500 |
50 mg | 約6-8 週間 | ¥ 165,500 |
100 mg | 約6-8 週間 | ¥ 229,000 |
1 mL * 10 mM (in DMSO) | 約 5 days | ¥ 50,000 |
説明 | RO-9187 is an effective HCV virus replication inhibitor(IC50: 171 nM). |
ターゲット&IC50 | HCV:171 nM |
In vitro | RO-9187 suppresses RNA synthesis by HCV polymerases from either HCV genotypes 1a and 1b or containing S96T or S282T point mutations with similar potencies, suggesting no cross-resistance with either R1479 or 2′-C-methyl nucleosides. RO-9187 is excellent substrates for deoxycytidine kinase and is phosphorylated with efficiencies up to 3-fold higher than deoxycytidine. The formation of RO-9187-TP increased in a time- and dose-dependent manner [1]. |
In vivo | Plasma exposures of RO-9187 in rats increase in a dose-dependent manner between 10 and 2000 mg/kg after oral dosing. Plasma concentrations of RO-9187 (1.4 and 26 μM ) are achieved in rats and dogs at the 10 mg/kg dose level, respectively. Plasma concentrations up to 57 μM are achieved in rats dosed with RO-9187 (2000 mg/kg/day)[1]. |
分子量 | 284.23 |
分子式 | C9H12N6O5 |
CAS No. | 876708-03-1 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
H2O: 7.14 mg/mL (25.12 mM), Sonication is recommended.
You can also refer to dose conversion for different animals. 詳細
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RO-9187 876708-03-1 Microbiology/Virology Proteases/Proteasome HCV Protease RO 9187 RO9187 Inhibitor inhibitor inhibit