store at low temperature
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Ralaniten (EPI-002) is a potent, specific, and orally active antagonist of the androgen receptor N-terminal structural domain (AR-NTD).Ralaniten inhibits AR transcriptional activity with an IC50 value of 7.4 μM.Ralanites have anticancer activity and can be used to study desmoplasia-resistant prostate cancer (CRPC).
説明 | Ralaniten (EPI-002) is a potent, specific, and orally active antagonist of the androgen receptor N-terminal structural domain (AR-NTD).Ralaniten inhibits AR transcriptional activity with an IC50 value of 7.4 μM.Ralanites have anticancer activity and can be used to study desmoplasia-resistant prostate cancer (CRPC). |
ターゲット&IC50 | AR-NTD:7.4 μM (IC50) |
In vitro |
Ralaniten(5-35 μM; 2-3 days) reduces AR-dependent proliferation of LNCaP cells and has no effect on the viability of PC3 human prostate cancer cells that do not express functional AR.[1] Ralaniten (10-35 μM; 4 hours) inhibits forskolin-induced transactivation of the AR N-terminal domain (NTD) in LNCaP cells.[1] |
In vivo | Ralaniten (100 mg/kg; taken orally twice daily for 28 days; Male NOD-SCID mice bearing subcutaneous tumors were castrated) inhibits VCaP tumor growth in castrated mice.[1] |
別名 | EPI-002 |
分子量 | 394.89 |
分子式 | C21H27ClO5 |
CAS No. | 1203490-23-6 |
store at low temperature
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 90 mg/mL (227.91 mM), Sonication is recommended.
You can also refer to dose conversion for different animals. 詳細
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Ralaniten 1203490-23-6 Endocrinology/Hormones Androgen Receptor EPI 002 EPI-002 EPI002 Inhibitor inhibitor inhibit