Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Roniciclib (BAY 1000394) is a potent pan-CDK inhibitor and a novel oral cytotoxic agent. Roniciclib inhibits the activity of cell-cycle CDKs CDK1, CDK2, CDK3, CDK4, and of transcriptional CDKs CDK7 and CDK9 with IC(50) values in the range between 5 and 25 nmol/L.
説明 | Roniciclib (BAY 1000394) is a potent pan-CDK inhibitor and a novel oral cytotoxic agent. Roniciclib inhibits the activity of cell-cycle CDKs CDK1, CDK2, CDK3, CDK4, and of transcriptional CDKs CDK7 and CDK9 with IC(50) values in the range between 5 and 25 nmol/L. |
ターゲット&IC50 | CDK2-CyclinE:9 nM, CDK4-CyclinD:11 nM, CDK9-CyclinT1:5 nM, CDK1-CyclinB:7 nM, CDK7-CyclinH-MAT1:25 nM |
別名 | BAY 1000394 |
分子量 | 430.44 |
分子式 | C18H21F3N4O3S |
CAS No. | 1223498-69-8 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 249 mg/mL (578.47 mM)
You can also refer to dose conversion for different animals. 詳細
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.
Roniciclib 1223498-69-8 Cell Cycle/Checkpoint CDK BAY 1000394 Cyclin dependent kinase BAY1000394 BAY-1000394 inhibit Inhibitor inhibitor